组胺药理学的进展揭示了新的药物靶点。
Advances in histamine pharmacology reveal new drug targets.
作者信息
Chazot Paul L
出版信息
Br J Pharmacol. 2009 May;157(1):1-3. doi: 10.1111/j.1476-5381.2009.00228.x.
Abstract
This Themed Issue consists of three reviews and 11 original articles authored by internationally respected industrial and academic pharmacologists from across three continents. It derives from the highly successful symposium on 'The H3 and H4 histamine receptors: the antihistamines for the 21(st) century', which took place at EPHAR 2008 in Manchester University, and encompasses new roles, new compounds and exciting new therapeutic areas for histamine.
摘要
本期专题由三篇综述和11篇原创文章组成，作者是来自三大洲的国际知名工业界和学术界药理学家。它源自于2008年在曼彻斯特大学举行的EPHAR会议上极为成功的关于“组胺H3和H4受体：21世纪的抗组胺药”的研讨会，涵盖了组胺的新作用、新化合物以及令人兴奋的新治疗领域。
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本文引用的文献
1
Use of the H3 receptor antagonist radioligand [3H]-A-349821 to reveal in vivo receptor occupancy of cognition enhancing H3 receptor antagonists.
Br J Pharmacol. 2009 May;157(1):139-49. doi: 10.1111/j.1476-5381.2009.00239.x.
2
Altered histamine H3 receptor radioligand binding in post-mortem brain samples from subjects with psychiatric diseases.
Br J Pharmacol. 2009 May;157(1):118-29. doi: 10.1111/j.1476-5381.2009.00149.x.
3
Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.
Br J Pharmacol. 2009 May;157(1):104-17. doi: 10.1111/j.1476-5381.2009.00205.x.
4
Effects of L-histidine depletion and L-tyrosine/L-phenylalanine depletion on sensory and motor processes in healthy volunteers.
Br J Pharmacol. 2009 May;157(1):92-103. doi: 10.1111/j.1476-5381.2009.00203.x.
5
Histamine H1 receptor knockout mice exhibit impaired spatial memory in the eight-arm radial maze.
Br J Pharmacol. 2009 May;157(1):86-91. doi: 10.1111/j.1476-5381.2009.00225.x.
6
Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors.
Br J Pharmacol. 2009 May;157(1):64-75. doi: 10.1111/j.1476-5381.2009.00152.x.
7
The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
Br J Pharmacol. 2009 May;157(1):55-63. doi: 10.1111/j.1476-5381.2009.00227.x.
8
In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties.
Br J Pharmacol. 2009 May;157(1):44-54. doi: 10.1111/j.1476-5381.2009.00236.x.
9
Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430.
Br J Pharmacol. 2009 May;157(1):34-43. doi: 10.1111/j.1476-5381.2009.00200.x.
10
Molecular and biochemical pharmacology of the histamine H4 receptor.
Br J Pharmacol. 2009 May;157(1):14-23. doi: 10.1111/j.1476-5381.2009.00250.x.
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