Repka-Ramirez Maria Susana
Division of Rheumatology, Immunology, and Allergy, Georgetown University Medical Center, GL-020 Gorman Building, 3800 Reservoir Road, Washington, DC 20007-2197, USA.
Curr Allergy Asthma Rep. 2003 May;3(3):227-31. doi: 10.1007/s11882-003-0044-3.
Histamine and antihistamines are so deeply woven into the fabric of allergic diseases that it is sometimes difficult to see how this field could advance beyond our current, potent histamine H1-receptor drugs. Investigations of other actions of histamine and the identification of H2, H3, and now H4 receptors have suddenly reignited the search for new mono- and multi-receptor-specific agonists and antagonists. There is great excitement due to preliminary findings that H3 receptors act as neural inhibitory autoreceptors, and H4 receptors might modulate immune cell functions.
组胺和抗组胺药与过敏性疾病紧密相连，以至于有时很难想象该领域如何能超越我们目前强效的组胺H1受体药物取得进展。对组胺其他作用的研究以及H2、H3以及现在H4受体的发现，突然重新燃起了对新型单受体和多受体特异性激动剂及拮抗剂的探索热情。由于初步研究结果显示H3受体作为神经抑制性自身受体发挥作用，且H4受体可能调节免疫细胞功能，人们为此兴奋不已。
