Bramness Jørgen G
Avdeling for legemiddelepidemiologi, Nasjonalt folkehelseinstitutt, Postboks 4404 Nydalen, 0881 Oslo.
Tidsskr Nor Laegeforen. 2009 Apr 30;129(9):855-7. doi: 10.4045/tidsskr.08.0276.
The Norwegian prescription database (NorPD) provides an opportunity to examine lithium consumption at an individual level. This article presents an assessment of lithium use (based on data from NorPD) in light of two population-based studies on prevalence of psychiatric illness in the counties Oslo and Sogn og Fjordane.
All persons between 18 and 65 years who received at least one prescription for lithium between July 2005 and June 2006 were identified in NorPD. County and gender specific prevalence rates, incidence rates, and average dose were calculated. Some pharmacoepidemiological parameters were derived.
The incidence of lithium users was 1.5 per 1000 inhabitants in Oslo and 5.5 in Sogn og Fjordane in the period assessed. The incidence was highest for men in Sogn og Fjordane. More lithium was prescribed to each patient in Oslo than in Sogn og Fjordane, and more was prescribed for men than women.
Patients with bipolar disease are apparently much more likely to be treated with lithium in Sogn og Fjordane than in Oslo. Previous estimates of the prevalence of bipolar disorder in Sogn og Fjordane are probably too low. In addition, there might be a broader indication for the use of lithium in this county.
挪威处方数据库（NorPD）为在个体层面研究锂的使用情况提供了契机。本文根据两项基于奥斯陆郡和松恩-菲尤拉讷郡精神病患病率的人群研究，对锂的使用情况（基于NorPD数据）进行了评估。
在NorPD中确定了2005年7月至2006年6月期间所有18至65岁且至少接受过一次锂处方的人。计算了郡和性别特异性患病率、发病率以及平均剂量。得出了一些药物流行病学参数。
在所评估的时期内，奥斯陆郡锂使用者的发病率为每1000名居民中有1.5人，松恩-菲尤拉讷郡为5.5人。松恩-菲尤拉讷郡男性的发病率最高。奥斯陆郡每位患者的锂处方量比松恩-菲尤拉讷郡多，且男性的处方量多于女性。
与奥斯陆郡相比，松恩-菲尤拉讷郡的双相情感障碍患者显然更有可能接受锂治疗。此前对松恩-菲尤拉讷郡双相情感障碍患病率的估计可能过低。此外，该郡可能对锂的使用有更广泛的指征。
