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Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.磷脂酰肌醇3激酶p110β活性：在代谢和乳腺癌中起关键作用，但与发育无关。
Sci Signal. 2008 Sep 9;1(36):ra3. doi: 10.1126/scisignal.1161577.
2
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.磷脂酰肌醇-3激酶-p110β在细胞生长、代谢和肿瘤发生中的重要作用。
Nature. 2008 Aug 7;454(7205):776-9. doi: 10.1038/nature07091. Epub 2008 Jun 25.
3
Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase.磷酸肌醇3激酶p110α和p110β调节细胞周期进入，在G1期表现出不同的激活动力学。
Mol Cell Biol. 2008 Apr;28(8):2803-14. doi: 10.1128/MCB.01786-07. Epub 2008 Feb 19.
4
The many faces of the origin recognition complex.复制起始识别复合体的多样面貌。
Curr Opin Cell Biol. 2007 Jun;19(3):337-43. doi: 10.1016/j.ceb.2007.04.007. Epub 2007 Apr 26.
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Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts.蛋白激酶C对成纤维细胞中p21cip1的转录后去稳定作用
J Biol Chem. 2006 Dec 15;281(50):38127-32. doi: 10.1074/jbc.M609622200. Epub 2006 Oct 16.
6
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.PI3-K家族的药理学图谱确定了p110α在胰岛素信号传导中的作用。
Cell. 2006 May 19;125(4):733-47. doi: 10.1016/j.cell.2006.03.035. Epub 2006 Apr 27.
7
Phosphoinositide 3-kinase controls early and late events in mammalian cell division.磷酸肌醇3激酶控制哺乳动物细胞分裂的早期和晚期事件。
EMBO J. 2006 Feb 22;25(4):655-61. doi: 10.1038/sj.emboj.7600967. Epub 2006 Jan 26.
8
Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase.I类磷酸肌醇3激酶的p110β、γ和δ亚型诱导的致癌转化。
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1289-94. doi: 10.1073/pnas.0510772103. Epub 2006 Jan 23.
9
Getting a grip on licensing: mechanism of stable Mcm2-7 loading onto replication origins.掌握许可机制：Mcm2-7稳定加载到复制起点的机制
Mol Cell. 2006 Jan 20;21(2):143-4. doi: 10.1016/j.molcel.2006.01.003.
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Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.Mrc1和Tof1独立于Rad53促进复制叉的进展和恢复。
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磷酸肌醇3激酶β在DNA复制调控中的特定功能。

Specific function of phosphoinositide 3-kinase beta in the control of DNA replication.

作者信息

Marqués Miriam, Kumar Amit, Poveda Ana M, Zuluaga Susana, Hernández Carmen, Jackson Shaun, Pasero Philippe, Carrera Ana C

机构信息

Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid E-28049, Spain.

出版信息

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7525-30. doi: 10.1073/pnas.0812000106. Epub 2009 Apr 22.

DOI:10.1073/pnas.0812000106
PMID:19416922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2678616/
Abstract

Class I(A) phosphoinositide 3-kinase (PI3K) are enzymes comprised of a p85 regulatory and a p110 catalytic subunit that induce formation of 3-polyphosphoinositides, which activate numerous downstream targets. PI3K controls cell division. Of the 2 ubiquitous PI3K isoforms, alpha has selective action in cell growth and cell cycle entry, but no specific function in cell division has been described for beta. We report here a unique function for PI3Kbeta in the control of DNA replication. PI3Kbeta regulated DNA replication through kinase-dependent and kinase-independent mechanisms. PI3Kbeta was found in the nucleus, where it associated PKB. Modulation of PI3Kbeta activity altered the DNA replication rate by controlling proliferating cell nuclear antigen (PCNA) binding to chromatin and to DNA polymerase delta. PI3Kbeta exerted this action by regulating the nuclear activation of PKB in S phase, and in turn phosphorylation of PCNA negative regulator p21(Cip). Also, p110beta associated with PCNA and controlled PCNA loading onto chromatin in a kinase-independent manner. These results show a selective function of PI3Kbeta in the control of DNA replication.

摘要

I（A）类磷酸肌醇3-激酶（PI3K）是由一个p85调节亚基和一个p110催化亚基组成的酶，可诱导3-多磷酸肌醇的形成，从而激活众多下游靶点。PI3K控制细胞分裂。在两种普遍存在的PI3K亚型中，α在细胞生长和细胞周期进入方面具有选择性作用，但尚未发现β在细胞分裂中有特定功能。我们在此报告PI3Kβ在控制DNA复制方面的独特功能。PI3Kβ通过激酶依赖性和激酶非依赖性机制调节DNA复制。PI3Kβ存在于细胞核中，并与蛋白激酶B（PKB）相关联。调节PI3Kβ的活性可通过控制增殖细胞核抗原（PCNA）与染色质及DNA聚合酶δ的结合来改变DNA复制速率。PI3Kβ通过在S期调节PKB的核激活，进而使PCNA负调节因子p21（Cip）磷酸化来发挥这一作用。此外，p110β与PCNA相关联，并以激酶非依赖性方式控制PCNA加载到染色质上。这些结果表明PI3Kβ在控制DNA复制方面具有选择性功能。