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Successful and well-tolerated second line therapy with cetuximab, irinotecan, and raltitrexed in progressive liver disease due to metastatic colon cancer.

作者信息

Geurs F, Vandewaeter S, Ponette S, Ponette J, Knape S, Demetter P

机构信息

Department of Oncology, RZ Sint-Maria, Halle, Belgium.

出版信息

J Gastrointest Cancer. 2008;39(1-4):26-8. doi: 10.1007/s12029-009-9060-4. Epub 2009 May 6.

DOI:10.1007/s12029-009-9060-4
PMID:19418267
Abstract
摘要

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[A review of chemotherapy for metastatic colon cancer].[转移性结肠癌化疗综述]
Farm Hosp. 2006 Nov-Dec;30(6):359-69. doi: 10.1016/s1130-6343(06)74007-7.
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Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers.伊立替康用于转移性结直肠癌:剂量强化及与新药物联合应用,包括生物反应调节剂。
Ann Oncol. 2003;14 Suppl 2:ii17-23. doi: 10.1093/annonc/mdg724.
6
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Acta Oncol. 2011 May;50(4):574-7. doi: 10.3109/0284186X.2010.546369.
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Complete resection of unresectable liver metastases from colorectal cancer without deterioration of liver function after cetuximab and irinotecan: two case reports.西妥昔单抗联合伊立替康治疗后,不可切除的结直肠癌肝转移灶实现完全切除且肝功能未恶化:两例病例报告
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Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors.每周使用顺铂可能会逆转实体瘤肝转移扩散所导致的肝功能障碍和黄疸。
Hepat Med. 2009 Oct 30;1:9-12. doi: 10.2147/hmer.s7574. eCollection 2009.

本文引用的文献

1
EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer.EPIC:西妥昔单抗联合伊立替康用于氟嘧啶和奥沙利铂治疗失败的转移性结直肠癌患者的III期试验。
J Clin Oncol. 2008 May 10;26(14):2311-9. doi: 10.1200/JCO.2007.13.1193. Epub 2008 Apr 7.
2
Effective second-line treatment with cetuximab and bevacizumab in a patient with hepatic metastases of colorectal cancer and hyperbilirubinemia.西妥昔单抗和贝伐单抗对一名患有结直肠癌肝转移和高胆红素血症患者的有效二线治疗。
Onkologie. 2007 Oct;30(10):509-12. doi: 10.1159/000106098. Epub 2007 Sep 21.
3
Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial.
晚期预后不良的结直肠癌患者序贯和联合化疗的不同策略(MRC FOCUS):一项随机对照试验
Lancet. 2007 Jul 14;370(9582):143-152. doi: 10.1016/S0140-6736(07)61087-3.
4
Dose-escalating and pharmacologic study of oxaliplatin in adult cancer patients with impaired hepatic function: a National Cancer Institute Organ Dysfunction Working Group study.奥沙利铂在肝功能受损成年癌症患者中的剂量递增及药理学研究:一项美国国立癌症研究所器官功能障碍工作组的研究
Clin Cancer Res. 2007 Jun 15;13(12):3660-6. doi: 10.1158/1078-0432.CCR-06-2385.
5
Synergistic antitumor activity of capecitabine in combination with irinotecan.卡培他滨与伊立替康联合应用的协同抗肿瘤活性。
Clin Colorectal Cancer. 2005 Jan;4(5):336-43. doi: 10.3816/ccc.2005.n.007.
6
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.西妥昔单抗单药治疗及西妥昔单抗联合伊立替康治疗伊立替康难治性转移性结直肠癌。
N Engl J Med. 2004 Jul 22;351(4):337-45. doi: 10.1056/NEJMoa033025.
7
A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863.伊立替康在肝功能或肾功能不全患者或既往接受盆腔放疗患者中的I期及药代动力学研究:癌症和白血病B组9863研究。
Ann Oncol. 2003 Dec;14(12):1783-90. doi: 10.1093/annonc/mdg493.
8
Pharmacology of oxaliplatin in solid tumor patients with hepatic dysfunction: a preliminary report of the National Cancer Institute Organ Dysfunction Working Group.奥沙利铂在肝功能不全实体瘤患者中的药理学:美国国立癌症研究所器官功能障碍工作组的初步报告
Semin Oncol. 2003 Aug;30(4 Suppl 15):14-9. doi: 10.1016/s0093-7754(03)00400-7.
9
Dosage adjustment and pharmacokinetic profile of irinotecan in cancer patients with hepatic dysfunction.肝功能不全癌症患者中伊立替康的剂量调整及药代动力学特征
J Clin Oncol. 2002 Nov 1;20(21):4303-12. doi: 10.1200/JCO.2002.03.123.
10
Raltitrexed: current clinical status and future directions.雷替曲塞:当前临床状况与未来发展方向
Ann Oncol. 2002 Apr;13(4):513-22. doi: 10.1093/annonc/mdf054.