Kasture Sanjay, Barhate Shrikant, Mohan Mahalaxmi, Ballero Mauro, Sanna Cinzia, Maxia Andrea
Department of Pharmacology, Mahatma Gandhi Vidyamandir's Pharmacy Collge, Nashik, Maharashtra, India.
Nat Prod Res. 2009;23(8):724-8. doi: 10.1080/14786410802346215.
The previous study showed that chronic treatment with Withania somnifera extract (WS) inhibited haloperidol-induced catalepsy. It is suggested that caffeine and WS may be useful adjuvants in pharmacotherapy of Parkinson's disease. There are no studies on the effect of haloperidol on mice withdrawn from caffeine or W. somnifera. We therefore studied the effect of a single administration of standardised WS containing 5.1% total withanolides (WS, 30 or 100 mg kg(-1) i.p.) and/or caffeine (3 mg kg(-1) i.p.) and withdrawal from 6 days treatment with WS and/or caffeine, on haloperidol-induced catalepsy in albino mice. Single administration of both WS and caffeine, used either alone or in combination, significantly inhibited catalepsy. Mice withdrawn from caffeine significantly inhibited haloperidol-induced catalepsy, but mice withdrawn from WS showed increased catalepsy. The study indicated that withdrawal from WS does not retain anticataleptic activity, and caffeine but not WS may be a good adjuvant in pharmacotherapy of Parkinson's disease.
先前的研究表明，用印度人参提取物（WS）进行长期治疗可抑制氟哌啶醇诱导的僵住症。有人提出，咖啡因和WS可能是帕金森病药物治疗中的有用佐剂。目前尚无关于氟哌啶醇对停用咖啡因或印度人参的小鼠影响的研究。因此，我们研究了单次给予含5.1%总甾醇内酯的标准化WS（WS，30或100 mg kg⁻¹腹腔注射）和/或咖啡因（3 mg kg⁻¹腹腔注射），以及停用6天WS和/或咖啡因后，对白化病小鼠氟哌啶醇诱导的僵住症的影响。单独或联合使用WS和咖啡因进行单次给药，均能显著抑制僵住症。停用咖啡因的小鼠能显著抑制氟哌啶醇诱导的僵住症，但停用WS的小鼠僵住症增加。该研究表明，停用WS不能保留抗僵住症活性，并且咖啡因而非WS可能是帕金森病药物治疗中的良好佐剂。
