(+)-紫堇灵和(+)-别紫堇灵的立体选择性不对称合成。
Stereoselective asymmetric synthesis of (+)-sedamine and (+)-allosedamine.
机构信息
Université des Sciences et Technologies de Lille 1, LCOP, Bâtiment C3(2), 59655 Villeneuve d'Ascq, France.
出版信息
Chirality. 2010 Feb;22(2):212-6. doi: 10.1002/chir.20729.
PMID:19418554
Abstract
A convenient method for the generation of (+)-sedamine and (+)-allosedamine in high optical purity has been elaborated. The key steps are the highly stereoselective 1,2-nucleophilic addition to SAMP hydrazones allowing the installation of the stereogenic center at C2 and ring closing metathesis.
摘要
已经详细阐述了一种以高光学纯度生成（+）-西贝母碱和（+）-别西贝母碱的简便方法。关键步骤是对 SAMP 腙进行高立体选择性 1,2-亲核加成，从而在 C2 位引入手性中心并进行闭环复分解反应。
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