Morton J J, Beattie E C, Griffin S A, MacPherson F
MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK.
J Hum Hypertens. 1991 Aug;5 Suppl 1:9-14.
All forms of established hypertension are characterised by hypertrophy of the heart and blood vessels. Although these structural alterations are a normal adaptation to raised blood pressure, it has been suggested that hypertrophy may develop by a mechanism independent of pressure. Some investigators claim that in the young spontaneously hypertensive rat, hypertrophy of the blood vessels and heart is present at a time before the rise in pressure. Evidence also exists to support the role of angiotensin II in directly influencing growth within the vasculature. The present study confirms that hypertrophy of the mesenteric resistance vessels is present in the 3-week old spontaneously hypertensive rat. However, enhanced vascular structure was also associated with a higher mean arterial blood pressure. No increase in activity of the renin-angiotensin system could be detected. These observations raise doubts as to whether hypertrophy of the blood vessels can develop independently of raised pressure.
所有已确诊的高血压形式都以心脏和血管肥厚为特征。尽管这些结构改变是对血压升高的正常适应性反应，但有人提出，肥厚可能通过一种与压力无关的机制发展。一些研究人员声称，在年轻的自发性高血压大鼠中，血管和心脏的肥厚在血压升高之前就已出现。也有证据支持血管紧张素II在直接影响血管系统内生长方面的作用。本研究证实，3周龄的自发性高血压大鼠存在肠系膜阻力血管肥厚。然而，血管结构增强也与较高的平均动脉血压有关。未检测到肾素-血管紧张素系统活性增加。这些观察结果让人怀疑血管肥厚是否能在血压不升高的情况下发展。
