冠心病中C反应蛋白与冠状动脉钙化积分的关联
Association between C-reactive protein and coronary calcium score in coronary artery disease.
作者信息
Hosseinsabet A, Mohebbi A, Almasi A
机构信息
Department of Cardiology, Shaheed Rajaei Cardiovascular Center, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Cardiovasc J Afr. 2009 Mar-Apr;20(2):107-11.
BACKGROUND
Both high-sensitivity C-reactive protein (hs- CRP) and spiral computed tomography coronary artery calcium score (CCS) are valid markers of cardiovascular risk. It is unknown whether hs-CRP is a marker of atherosclerotic burden or if it reflects a process leading to acute coronary events.
METHODS AND RESULTS
We studied the association between hs- CRP and CCS in 143 patients who were candidates for coronary artery bypass grafting (CABG). In our cross-sectional study, we found no significant association between hs-CRP and the CCS in bivariant (p = 0.162) and multivariant (p = 0.062) analyses. However, in patients who did not use statins, this association was significant and positive in the bivariant analysis (p = 0.001), but in the multivariant analysis it was negative and significant (p = 0.008).
CONCLUSION
High-sensitivity CRP was not correlated with CCS. The relationship between CRP and clinical events might not be related to atherosclerotic burden. Measures of inflammation, such as hs-CRP, and indices of atherosclerosis, such as CCS, are likely to provide distinct information regarding cardiovascular risk.
背景
高敏C反应蛋白（hs-CRP）和螺旋计算机断层扫描冠状动脉钙化评分（CCS）都是心血管风险的有效标志物。目前尚不清楚hs-CRP是动脉粥样硬化负担的标志物，还是反映导致急性冠状动脉事件的过程。
方法与结果
我们研究了143例冠状动脉旁路移植术（CABG）候选患者中hs-CRP与CCS之间的关联。在我们的横断面研究中，双变量分析（p = 0.162）和多变量分析（p = 0.062）均未发现hs-CRP与CCS之间存在显著关联。然而，在未使用他汀类药物的患者中，双变量分析中这种关联显著且呈正相关（p = 0.001），但在多变量分析中呈负相关且显著（p = 0.008）。
结论
高敏CRP与CCS不相关。CRP与临床事件之间的关系可能与动脉粥样硬化负担无关。炎症指标如hs-CRP和动脉粥样硬化指标如CCS可能会提供关于心血管风险的不同信息。
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