Kim Hyungjin, Akagi Takami, Akashi Mitsuru
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan.
Macromol Biosci. 2009 Sep 9;9(9):842-8. doi: 10.1002/mabi.200800367.
Size tunable amphiphilic NPs composed of poly(gamma-PGA) and hydrophobic amino acids, such as Phe or Trp, were prepared. To prepare these size-regulated NPs, gamma-PGA-g-Phe or gamma-PGA-g-Trp dissolved in DMSO was added to various concentrations of NaCl solution. The gamma-PGA-Phe and gamma-PGA-Trp formed monodispersed NPs, and the size of NPs can be easily controlled by NaCl concentration. The different-sized NPs showed the same structure. The encapsulation of protein into the different-sized NPs was successfully achieved and the size of protein-encapsulated gamma-PGA-Phe NPs was increased when protein was encapsulated.
制备了由聚（γ-聚谷氨酸）和疏水性氨基酸（如苯丙氨酸或色氨酸）组成的尺寸可调的两亲性纳米粒子。为了制备这些尺寸可控的纳米粒子，将溶解在二甲基亚砜中的γ-聚谷氨酸-g-苯丙氨酸或γ-聚谷氨酸-g-色氨酸添加到不同浓度的氯化钠溶液中。γ-聚谷氨酸-苯丙氨酸和γ-聚谷氨酸-色氨酸形成了单分散的纳米粒子，并且纳米粒子的尺寸可以通过氯化钠浓度轻松控制。不同尺寸的纳米粒子显示出相同的结构。成功地将蛋白质包裹到不同尺寸的纳米粒子中，并且当包裹蛋白质时，包裹蛋白质的γ-聚谷氨酸-苯丙氨酸纳米粒子的尺寸增加。
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