Bongiorno David, Ceraulo Leopoldo, Camarda Lorenzo, Ciofalo Maurizio, Ferrugia Mirella, Indelicato Serena, Mele Andrea, Liveri Vincenzo Turco
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Palermo, Via Archirafi 32, I-90123 Palermo, Italy.
Eur J Mass Spectrom (Chichester). 2009;15(2):199-208. doi: 10.1255/ejms.968.
The gas-phase ion chemistry of protonated melatonin has been investigated by mass spectrometric (MS) techniques involving chemical ionisation, fast atom bombardment and electrospray ionisation. Either naturally- occurring or collision-induced decomposition e-D derivatives obtained by exchange with D(2)O. The analysis of experimental results allows definite pathways for the formation of the ion at m/z 174 to be assigned and sheds some more light on the overall fragmentation pathways. Experiments on labelled derivatives evidenced H-D scrambling processes during fragmentation.
已通过涉及化学电离、快原子轰击和电喷雾电离的质谱（MS）技术研究了质子化褪黑素的气相离子化学。通过与D₂O交换获得天然存在的或碰撞诱导分解的氘代衍生物。对实验结果的分析确定了m/z 174处离子形成的明确途径，并为整体碎裂途径提供了更多线索。对标记衍生物的实验证明了碎裂过程中的氢-氘重排过程。
