Souza R Canzi Almada de, Lima José Hermênio Cavalcante
Department of Clinical Medicine, Division of Gastroenterology, Federal University of Paraná, Curitiba-PR-CEP, Brazil.
Dis Esophagus. 2009;22(3):256-63. doi: 10.1111/j.1442-2050.2008.00911.x.
A possible association between gastroesophageal reflux disease (GERD) and Helicobacter pylori (H. pylori) infection has been the subject of study and debate in recent years. This review discusses the pathophysiological and immunological mechanisms implicated in this relationship. Although gastric secretion in the majority of H. pylori-infected individuals is unaltered, this review considers how the bacteria may interfere with gastric acid production and what role it may play in GERD. We also identify the epidemiological evidence that confirms that GERD develops after the infection has been eradicated. Lastly, we clarify how the host's immune response and bacterial virulence factors interfere with this relationship, explaining the highly conflicting results in the literature.
近年来，胃食管反流病（GERD）与幽门螺杆菌（H. pylori）感染之间可能存在的关联一直是研究和争论的主题。本综述讨论了这种关系中涉及的病理生理和免疫机制。尽管大多数感染幽门螺杆菌的个体胃酸分泌未改变，但本综述探讨了该细菌可能如何干扰胃酸分泌以及它在胃食管反流病中可能起的作用。我们还确定了流行病学证据，证实胃食管反流病在感染根除后才会发生。最后，我们阐明了宿主的免疫反应和细菌毒力因子如何干扰这种关系，解释了文献中高度矛盾的结果。
