Suda K
Department of Pathology, Yamanashi Medical University.
Rinsho Byori. 1991 Sep;39(9):977-80.
A histopathological study on fat necrosis with a comparison between patients in agonal stage and those with acute pancreatitis was presented. Fat necrosis was observed in 15 out of 56 autopsied cases (26.8%) which were selected randomly from the autopsy file. Fat necrosis was frequently stained blue or purple with Nile blue stain, suggestive of acid lipid. The necrosis was usually accompanied by fibrin thrombi in the capillaries and reparative foam cells, nor hemorrhage and hemosiderin deposition. In acute pancreatitis fat necrosis also reacted blue or purple with Nile blue stain in 8 out of 9 patients. Reparative reaction was composed of granulation tissue in 6 patients, frequently with organized thrombosis in the veins. Fat necrosis was accompanied by fibrin thrombi and either hemorrhage or hemosiderin deposition. Therefore, differences in both hemorrhage or hemosiderin deposition and reparative change were observed in fat necrosis between patients in agonal stage and those with acute pancreatitis.
本文呈现了一项关于脂肪坏死的组织病理学研究，并对濒死期患者和急性胰腺炎患者进行了比较。从尸检档案中随机选取了56例尸检病例，其中15例（26.8%）观察到脂肪坏死。脂肪坏死经尼罗蓝染色后常呈蓝色或紫色，提示酸性脂质。坏死通常伴有毛细血管内的纤维蛋白血栓和修复性泡沫细胞，而非出血和含铁血黄素沉积。在急性胰腺炎中，9例患者中有8例的脂肪坏死经尼罗蓝染色后也呈蓝色或紫色。6例患者的修复反应由肉芽组织组成，静脉中常伴有机化血栓形成。脂肪坏死伴有纤维蛋白血栓以及出血或含铁血黄素沉积。因此，在濒死期患者和急性胰腺炎患者的脂肪坏死中，观察到了出血或含铁血黄素沉积以及修复变化的差异。
