Thomas KaMala S, Nelesen Richard A, Ziegler Michael G, Natarajan Loki, Dimsdale Joel E
UCLA Cousins Center for Psychoneuroimmunology, Los Angeles, CA 90095-7076, United States.
Biol Psychol. 2009 Sep;82(1):18-24. doi: 10.1016/j.biopsycho.2009.04.007. Epub 2009 May 7.
Although neighborhood disadvantage has been linked to the development of cardiovascular disease, the mechanism through which living in impoverished neighborhoods is associated with poor cardiovascular health is not well understood. Additionally, it is not clear whether individual socioeconomic status (SES) interacts with neighborhood factors to influence cardiovascular outcomes. Using multilevel modeling, we examined the interaction between neighborhood poverty and individual SES on pressor responses to an alpha agonist, phenylephrine (PE), in an adult sample of 105 African-Americans and 106 Caucasian-Americans. Neighborhood poverty was assessed using census block data gathered from the Census Bureau. Education and occupation were used to assess individual SES. Pressor responsiveness was calculated as the systolic and diastolic blood pressure (BP) response to a 100-microg PE bolus administered intravenously. There was a significant interaction between education and neighborhood poverty on pressor responses. Higher education was associated with smaller BP responses to PE; but only in individuals who lived in neighborhoods in which less than 5% of the residents lived below the poverty line. Occupation was unrelated to pressor responses to PE. These results suggest that neighborhood characteristics play an important role in cardiovascular functioning.
尽管社区劣势与心血管疾病的发生有关，但生活在贫困社区与心血管健康状况不佳之间的关联机制尚不清楚。此外，个体社会经济地位（SES）是否与社区因素相互作用以影响心血管疾病的结局也不明确。我们采用多水平模型，在105名非裔美国成年人和106名高加索美国成年人样本中，研究了社区贫困与个体SES对α受体激动剂去氧肾上腺素（PE）的升压反应之间的相互作用。使用从人口普查局收集的普查街区数据评估社区贫困情况。通过教育程度和职业来评估个体SES。升压反应性的计算方法是静脉注射100微克PE推注后的收缩压和舒张压（BP）反应。教育程度与社区贫困之间在升压反应上存在显著的相互作用。高等教育与对PE的较小BP反应相关；但仅在居住于居民中低于贫困线的比例不到5%的社区中的个体中如此。职业与对PE的升压反应无关。这些结果表明，社区特征在心血管功能中起着重要作用。
