Hung Ching-Hsia, Wang Jhi-Joung, Chen Yu-Chung, Chu Chin-Chen, Chen Yu-Wen
Department of Physical Therapy, National Cheng Kung University, Tainan, Taiwan.
Neurosci Lett. 2009 May 1;454(3):249-53. doi: 10.1016/j.neulet.2009.03.018. Epub 2009 Mar 11.
Proxymetacaine and oxybuprocaine were clinically used for topical ocular anesthesia but never for spinal anesthesia, and therefore spinal anesthetic effects of proxymetacaine and oxybuprocaine were performed and compared with bupivacaine and lidocaine. After rats were injected intrathecally with proxymetacaine, oxybuprocaine, bupivacaine, and lidocane, dose-response curves were constructed. We evaluated the potencies (ED(50)) and durations (time to full recovery) of proxymetacaine and oxybuprocaine on spinal blockades of motor function, proprioception, and nociception and compared with bupivacaine and lidocaine in rats. We found that proxymetacaine and oxybuprocaine acted like bupivacaine or lidocaine and produced dose-related spinal blockades of motor function, proprioception and nociception. On the ED(50) basis, the ranks of potencies in motor, proprioception, and nociception were proxymetacaine>oxybuprocaine>bupivacaine>lidocaine (P<0.01 for the differences). On an equipotent basis (ED(20), ED(50), ED(80)), oxybuprocaine and bupivacaine produced similarly longer spinal blockades than did proxymetacaine or lidocaine (P<0.05 for the differences). Intrathecal proxymetacaine, oxybuprocaine, and bupivacaine also produced longer sensory blockade than motor blockade. These data demonstrated that oxybuprocaine and proxymetacaine produced more potent spinal blockades, when compared with bupivacaine or lidocaine. Oxybuprocaine and bupivacaine with a more sensory-selective action over motor blockade produced longer spinal blockade than did proxymetacaine or lidocaine.
丙美卡因和奥布卡因临床上用于眼部表面麻醉，但从未用于脊髓麻醉，因此对丙美卡因和奥布卡因的脊髓麻醉效果进行了研究，并与布比卡因和利多卡因进行比较。给大鼠鞘内注射丙美卡因、奥布卡因、布比卡因和利多卡因后，构建剂量-反应曲线。我们评估了丙美卡因和奥布卡因对大鼠运动功能、本体感觉和痛觉脊髓阻滞的效能（ED50）和持续时间（完全恢复时间），并与布比卡因和利多卡因进行比较。我们发现丙美卡因和奥布卡因的作用与布比卡因或利多卡因相似，可产生与剂量相关的运动功能、本体感觉和痛觉脊髓阻滞。在ED50基础上，运动、本体感觉和痛觉的效能排序为丙美卡因>奥布卡因>布比卡因>利多卡因（差异P<0.01）。在等效剂量（ED20、ED50、ED80）基础上，奥布卡因和布比卡因产生的脊髓阻滞持续时间比丙美卡因或利多卡因更长（差异P<0.05）。鞘内注射丙美卡因、奥布卡因和布比卡因产生的感觉阻滞也比运动阻滞持续时间更长。这些数据表明，与布比卡因或利多卡因相比，奥布卡因和丙美卡因产生的脊髓阻滞更强效。与丙美卡因或利多卡因相比，奥布卡因和布比卡因对运动阻滞具有更强的感觉选择性作用，产生的脊髓阻滞持续时间更长。
