Geidel S, Garn M, Grävinghoff L, Hausdorf G, Morf G, Bielack S, Knop J, Winkler K
Kinderklinik der Universität Hamburg.
Klin Padiatr. 1991 Jul-Aug;203(4):257-61. doi: 10.1055/s-2007-1025438.
The frequency and severity of clinical and subclinical heart damage were studied in patients who had been treated with adriamycin (ADR) as part of the Cooperative Osteosarcoma Studies (COSS). The study charts of 785 patients from 63 participating institutions were reviewed: The overall incidence of drug-induced congestive heart failure was 2.2% (17 cases, 5 fatal). Late left ventricular function was studied in 29 tumor free survivors 81 +/- 41 month after treatment with 342 +/- 113 mg/m2 ADR. A detailed history and physical exam for signs of overt heart disease were obtained. M-mode echocardiography (ECHO, 29 cases) with evaluation of the fractional shortening rate (FS) and radionuclide ventriculography (RNV, 18 cases) with determination of the systolic ejection fraction at rest (EF) were used to screen for subclinical cardiac disease. Impaired cardiac function leading to pathological values was documented in close to one half of these patients. The frequency and severity of clinical and subclinical heart damage increased with cumulative adriamycin and time since cessation of anthracycline therapy.
在作为骨肉瘤协作研究（COSS）一部分接受阿霉素（ADR）治疗的患者中，对临床和亚临床心脏损伤的频率及严重程度进行了研究。回顾了来自63个参与机构的785例患者的研究图表：药物性充血性心力衰竭的总体发生率为2.2%（17例，5例死亡）。在29例无肿瘤存活者中，于接受342±113mg/m²阿霉素治疗后81±41个月研究晚期左心室功能。获取了关于明显心脏病体征的详细病史和体格检查结果。采用评估缩短分数（FS）的M型超声心动图（ECHO，29例）和测定静息时收缩射血分数（EF）的放射性核素心室造影（RNV，18例）来筛查亚临床心脏疾病。近一半的这些患者记录到导致病理值的心脏功能受损。临床和亚临床心脏损伤的频率及严重程度随阿霉素累积剂量和蒽环类药物治疗停止后的时间而增加。
