Tadzhiev I Ia
Klin Med (Mosk). 1991 Jul;69(7):70-4.
Upon studying the factors contributory to development of acalculous and calculous cholecystitis it was found that bioelement composition and physicochemical properties of the bile undergo marked changes. These become more pronounced in hyperproduction of secondarylipid peroxides. Being responsible for conformation changes of biliary macromolecular structures and for cytolysis of cellular elements, hyperlipoperoxidation can determine the signs of their antigenic specificity as well as the onset of hypercholesterol- andhigh bile level of bilirubin as confirmed in guinea pig experiments. Hyperlipoperoxidation proved a powerful colloid-destabilizing factor of the bile able to trigger lithogenesis.
在研究促成无结石性和结石性胆囊炎发展的因素时发现，胆汁的生物元素组成和物理化学性质会发生显著变化。在继发性脂质过氧化物过度产生时，这些变化会更加明显。高脂过氧化作用会导致胆汁大分子结构的构象变化和细胞成分的细胞溶解，它能够决定其抗原特异性的迹象以及高胆固醇血症和高胆红素胆汁水平的出现，这在豚鼠实验中得到了证实。高脂过氧化作用被证明是胆汁中一种强大的胶体不稳定因素，能够引发结石形成。
