[The role of hyperlipoperoxidation in the development of chronic acalculous and calculous cholecystitis].

Upon studying the factors contributory to development of acalculous and calculous cholecystitis it was found that bioelement composition and physicochemical properties of the bile undergo marked changes. These become more pronounced in hyperproduction of secondarylipid peroxides. Being responsible for conformation changes of biliary macromolecular structures and for cytolysis of cellular elements, hyperlipoperoxidation can determine the signs of their antigenic specificity as well as the onset of hypercholesterol- andhigh bile level of bilirubin as confirmed in guinea pig experiments. Hyperlipoperoxidation proved a powerful colloid-destabilizing factor of the bile able to trigger lithogenesis.