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治疗主动脉瓣狭窄的新技术——使用爱德华SAPIEN心脏瓣膜进行经导管主动脉瓣植入术

New techniques for the treatment of valvular aortic stenosis--transcatheter aortic valve implantation with the SAPIEN heart valve.

作者信息

Thielmann Matthias, Eggebrecht Holger, Wendt Daniel, Kahlert Phillip, Ideler Ben, Kottenberg-Assenmacher Eva, Erbel Raimund, Jakob Heinz

机构信息

Department of Thoracic and Cardiovascular Surgery, Essen, Germany.

出版信息

Minim Invasive Ther Allied Technol. 2009;18(3):131-41. doi: 10.1080/13645700902917920.

Abstract

Acquired aortic stenosis (AS) resulting from calcification of the aortic valve is the most frequent acquired valve disease in Europe. Due to the increasing average life expectancy the population in the western industrial world is aging, and consequently the prevalence of AS requiring aortic valve replacement (AVR), particularly in older patients, is continuously increasing. However, the risk of conventional AVR with the use of sternotomy, cardiopulmonary bypass, and cardioplegic cardiac arrest is obviously higher in the elderly patient, in whom significant comorbidities may additionally pre-exist. Moreover, there is recent evidence that 30-40% of the patients with severe and/or symptomatic AS in Europe remain untreated and nearly half of them are considered "too sick" for surgery. Thus, there seems to be a role for less invasive treatment options, like transcatheter aortic valve implantation (TAVI) techniques, addressing an unmet patient and medical need. Today, an increasing number of different transcatheter heart valve devices for aortic valve implantation is coming up; however, so far only for two systems there is broad clinical experience with human implantations. The following article is aimed to describe the current transcatheter aortic valve implantation technique with full details of the procedural steps, both via the transfemoral and via the transapical access using the balloon-expandable SAPIEN transcatheter aortic heart valve device.

摘要

由主动脉瓣钙化导致的获得性主动脉瓣狭窄(AS)是欧洲最常见的获得性瓣膜疾病。由于平均预期寿命的增加,西方工业世界的人口正在老龄化,因此需要进行主动脉瓣置换(AVR)的AS患病率,尤其是在老年患者中,正在持续上升。然而,对于老年患者,采用胸骨切开术、体外循环和心脏停搏的传统AVR风险明显更高,而且这些患者可能还存在显著的合并症。此外,最近有证据表明,欧洲30%至40%的重度和/或有症状的AS患者仍未得到治疗,其中近一半被认为“病情过重”无法进行手术。因此,对于经导管主动脉瓣植入(TAVI)技术等侵入性较小的治疗选择而言,似乎有发挥作用的空间,以满足未得到满足的患者需求和医疗需求。如今,越来越多不同的用于主动脉瓣植入的经导管心脏瓣膜装置不断涌现;然而,到目前为止,只有两种系统有广泛的人体植入临床经验。以下文章旨在详细描述当前的经导管主动脉瓣植入技术,包括经股动脉和经心尖途径使用球囊扩张式SAPIEN经导管主动脉心脏瓣膜装置的操作步骤的全部细节。

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