Bleiziffer Sabine, Ruge Hendrik, Mazzitelli Domenico, Schreiber Christian, Hutter Andrea, Laborde Jean-Claude, Bauernschmitt Robert, Lange Ruediger
Clinic for Cardiovascular Surgery, German Heart Center Munich, Lazarettstr. 36, 80636 Munich, Germany.
Eur J Cardiothorac Surg. 2009 Apr;35(4):615-20; discussion 620-1. doi: 10.1016/j.ejcts.2008.12.041. Epub 2009 Feb 23.
Transcatheter aortic valve implantation has been performed by several groups, most of them either specializing on the transapical (surgeons) or the percutaneous femoral transarterial approach (cardiologists). We achieved both transapical and percutaneous transcatheter valve implantation by a surgical team in a hybrid suite.
Since June 2007, 137 patients (n=78 female, mean age 81+/-7 years) underwent transcatheter aortic valve implantation (n=109 transfemoral, n=3 via subclavian artery, n=2 directly through ascending aorta, n=23 transapical) with the CoreValve (n=114) or the Edwards Sapien (n=23) prosthesis.
Thirty-day mortality was 12.4% in this patient cohort. One hundred and eight patients (78.8%) are alive at a mean follow-up of 97+/-82 days. Pacemaker implantation due to postoperative AV block was performed in 27 patients (19.7%), and 7 patients (5.1%) sustained neurological events. Patients improved in NYHA class (from 3.1+/-0.3 to 1.9+/-0.5, p<0.001) and in self-assessed health state (from 55+/-17% to 68+/-16%, p<0.001) at one-month follow-up. Echocardiographic assessment revealed excellent hemodynamic function of the prostheses with a mean aortic gradient (MAG) of 11.9+/-4.4 mmHg and an effective orifice area (EOA) of 1.6+/-0.4 cm(2) at discharge and a MAG of 11.0+/-4.2 mmHg and an EOA of 1.6+/-0.3 cm(2) at six months FU.
Transcatheter aortic valve implantation has become an alternative technique for the treatment of aortic stenosis with reasonable short- and mid-term results at our institution. With the opportunity to treat aortic stenosis by conventional surgical valve replacement and transapical and percutaneous transcatheter procedures, the technique of lowest risk for the individual patient can be chosen and performed by one team.
多个团队已开展经导管主动脉瓣植入术,其中大多数团队要么专注于经心尖途径(外科医生),要么专注于经皮股动脉途径(心脏病专家)。我们的外科团队在杂交手术室中实现了经心尖和经皮经导管瓣膜植入。
自2007年6月起,137例患者(78例女性,平均年龄81±7岁)接受了经导管主动脉瓣植入术(109例经股动脉,3例经锁骨下动脉,2例直接经升主动脉,23例经心尖),使用CoreValve瓣膜(114例)或Edwards Sapien瓣膜(23例)。
该患者队列的30天死亡率为12.4%。108例患者(78.8%)在平均97±82天的随访期内存活。27例患者(19.7%)因术后房室传导阻滞植入起搏器,7例患者(5.1%)发生神经系统事件。患者在1个月随访时纽约心脏协会心功能分级改善(从3.1±0.3改善至1.9±0.5,p<0.001),自我评估健康状态改善(从55±17%改善至68±16%,p<0.001)。超声心动图评估显示瓣膜血流动力学功能良好,出院时平均主动脉瓣压差(MAG)为11.9±4.4 mmHg,有效瓣口面积(EOA)为1.6±0.4 cm²,6个月随访时MAG为11.0±4.2 mmHg,EOA为1.6±0.3 cm²。
在我们机构,经导管主动脉瓣植入术已成为治疗主动脉瓣狭窄的一种替代技术,短期和中期结果合理。由于有机会通过传统外科瓣膜置换、经心尖和经皮经导管手术治疗主动脉瓣狭窄,可为个体患者选择风险最低的技术并由一个团队实施。