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玻璃体内曲安奈德注射治疗糖尿病性黄斑水肿后的黄斑功能。

Macular function after intravitreal triamcinolone acetonide injection for diabetic macular oedema.

机构信息

Istanbul Retina Institute Inc., Istanbul, Turkey.

出版信息

Acta Ophthalmol. 2010 Aug;88(5):558-63. doi: 10.1111/j.1755-3768.2008.01497.x. Epub 2009 Apr 27.

Abstract

PURPOSE

We aimed to evaluate the effect of intravitreal triamcinolone acetonide (IVTA) on macular function in patients with diabetic macular oedema (DMO).

METHODS

Eleven eyes in 11 patients with DMO were enrolled. In each eye, at baseline and at 30 days after IVTA injection, logMAR visual acuity (VA), macular sensitivity, fixation stability and fixation location by MP-1 microperimetry and optical coherence tomography (OCT) foveal thickness were assessed.

RESULTS

Thirty days after IVTA injection, eyes with DMO showed a significant (p<0.001) reduction in foveal thickness and significant (p<0.01) increases in logMAR VA and MP-1 retinal sensitivity (p<0.001). There was also significant (p=0.046) improvement in fixation location and some improvement in fixation stability, although the latter was not significant (p=0.08).

CONCLUSIONS

In eyes with DMO, short-term improvement in retinal sensitivity and fixation properties can be achieved by IVTA injection.

摘要

目的

评估玻璃体内曲安奈德(IVTA)注射对糖尿病性黄斑水肿(DMO)患者黄斑功能的影响。

方法

纳入 11 例 11 只眼的 DMO 患者。每只眼在基线时和 IVTA 注射后 30 天时,通过 MP-1 微视野计和光学相干断层扫描(OCT)评估黄斑敏感性、固视稳定性和固视位置。

结果

IVTA 注射 30 天后,DMO 眼的黄斑厚度显著降低(p<0.001),LogMAR 视力(VA)和 MP-1 视网膜敏感性显著增加(p<0.01)。固视位置也有显著改善(p=0.046),固视稳定性虽有改善但无统计学意义(p=0.08)。

结论

IVTA 注射可在短期内改善 DMO 眼的视网膜敏感性和固视特性。

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