腹腔镜袖状胃切除术对病态肥胖2型糖尿病患者的疗效
[Efficacy of laparoscopic sleeve gastrectomy on morbidly obese patients with type 2 diabetes mellitus].
作者信息
Li Xin-Xiang, Rosenthal Raul J, Zheng Cheng-Zhu
机构信息
Department of Abdominal Surgery, Affiliated Cancer Hospital, Fudan University, Shanghai 200032, China.
出版信息
Zhonghua Wei Chang Wai Ke Za Zhi. 2009 May;12(3):269-72.
OBJECTIVE
To evaluate the efficacy of laparoscopic sleeve gastrectomy(LSG) on improving glycemic control of morbidly obese patients with type 2 diabetes mellitus.
METHODS
Prospective study of 30 type 2 diabetes mellitus(T2DM) patients with BMI > or = 35 undergone LSG was carried out. Pre- and post-operative clinical parameters associated with diabetes mellitus 6 months after operation were evaluated. Data collected included demographics, weight loss(BMI, EWL%), diabetes control (FPG, HbA1C) and ghrelin.
RESULTS
Fasting plasma glucose and glycosylated hemoglobin concentration tests and clinical outcomes suggested LSG resulted in significant improvement or resolution of T2DM in all the 30 patients with CR 63%(19/30) and PR 37%(11/30).
CONCLUSIONS
LSG can lead to significant changes in controlling glycemia on morbidly obese patients with T2DM in 6 months. Long-term efficacy needs further follow-up.
目的
评估腹腔镜袖状胃切除术（LSG）对改善病态肥胖2型糖尿病患者血糖控制的疗效。
方法
对30例BMI≥35的2型糖尿病（T2DM）患者进行前瞻性研究，这些患者接受了LSG。评估术前和术后6个月与糖尿病相关的临床参数。收集的数据包括人口统计学资料、体重减轻情况（BMI、EWL%）、糖尿病控制情况（空腹血糖、糖化血红蛋白）和胃饥饿素。
结果
空腹血糖和糖化血红蛋白浓度检测及临床结果表明，LSG使所有30例患者的T2DM得到显著改善或缓解，完全缓解率为63%（19/30），部分缓解率为37%（11/30）。
结论
LSG可使病态肥胖T2DM患者在6个月内血糖控制发生显著变化。长期疗效需要进一步随访。
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