Gonzalez-Garrido A A, Barrios F A, de la Serna-Tuya J M, Cocula-León H, Gómez-Velázquez F R
Instituto de Neurociencias, Universidad de Guadalajara, Jalisco, Mexico.
Rev Neurol. 2009;48(10):509-14.
Attention deficit/hyperactivity disorder (ADHD) is a common behavioral disorder found mainly in males, thus current knowledge on its clinical expression in female adults is extremely limited. AIM. To evaluate the behavioral and neural substrates associated with the performance of a short-term memory task in female ADHD adults, with and without methylphenidate exposure, with respect to a control group.
Two groups of eight young right-handed, female, university students with ADHD and healthy controls matched by age, gender, handedness and academic level, voluntarily participated. All subjects performed twice an easy auditory short-term memory task (ADHD group without, and 90 minutes post-intake of methylphenidate 0.4 mg/kg in a counterbalanced order). The BOLD-fMRI response was used as a measure of neural activity during task performance.
ADHD subjects showed a tendency to improve their performances under medication, showing an increased widespread functional activation, especially relevant over left frontal and cerebellar areas, in comparison with control subjects.
Methylphenidate slightly improves short-term memory task performance in adult female ADHD subjects by modifying underlying neural functioning patterns.
注意力缺陷多动障碍（ADHD）是一种常见的行为障碍，主要见于男性，因此目前关于其在成年女性中的临床表现的知识极为有限。目的：评估成年女性ADHD患者在执行短期记忆任务时，无论是否接触哌甲酯，与对照组相比的行为和神经基础。
两组各8名年轻右利手女性大学生，一组为ADHD患者，另一组为健康对照，两组在年龄、性别、利手和学业水平上相匹配，均自愿参与。所有受试者均执行两次简单的听觉短期记忆任务（ADHD组一次不服用药物，另一次在摄入0.4mg/kg哌甲酯90分钟后，顺序采用平衡法）。任务执行期间，采用血氧水平依赖性功能磁共振成像（BOLD-fMRI）反应作为神经活动的测量指标。
与对照组相比，ADHD受试者在服药后表现出改善的趋势，功能激活广泛增加，尤其在左额叶和小脑区域更为明显。
哌甲酯通过改变潜在的神经功能模式，略微改善成年女性ADHD受试者的短期记忆任务表现。
