可卡因滥用患者神经元中的HIV-1抗原
HIV-1 Antigens in Neurons of Cocaine-Abusing Patients.
作者信息
Fiala Milan, Singer Elyse J, Commins Deborah, Mirzapoiazova Tamara, Verin Alexander, Espinosa Araceli, Ugen Kenneth, Bernas Michael, Witte Marlys, Weinand Martin, Lossinsky Albert S
机构信息
Departments of Medicine, UCLA School of Medicine, Los Angeles, California, USA.
出版信息
Open Virol J. 2008;2:24-31. doi: 10.2174/1874357900802010024. Epub 2008 Mar 28.
Cocaine opens the blood-brain barrier by deregulating transcription of target genes. Here we show that cocaine at blood concentrations in drug abusers disrupts endothelial cell junctions in parallel with signaling by phosphorylation of extracellular signal-regulated kinase, myristoylated alanine-rich C kinase and myosin light chain. Cocaine effects may be important in vivo since the neurons of drug abusing patients with HIV-1 associated dementia displayed gp120, p24 and Nef.
可卡因通过解除靶基因转录的调控来打开血脑屏障。我们在此表明，滥用药物者血液浓度的可卡因会破坏内皮细胞连接，同时伴随着细胞外信号调节激酶、肉豆蔻酰化富含丙氨酸的C激酶和肌球蛋白轻链磷酸化的信号传导。可卡因的作用在体内可能很重要，因为患有HIV-1相关痴呆的药物滥用患者的神经元显示出gp120、p24和Nef。
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