Seri S, Cerquiglini A, Cusmai R, Curatolo P
Istituto di Neuropsichiatria Infantile, Università La Sapienza, Rome, Italy.
Neurophysiol Clin. 1991 Aug;21(3):161-72. doi: 10.1016/s0987-7053(05)80423-x.
A group of 10 patients suffering from tuberous sclerosis (TS) and epilepsy was studied by means of topographic mapping of EEG and visual evoked potentials. The localizing ability of the technique was compared to the topography of hyperintense T2-dependent areas seen on magnetic resonance images (MRI). Data were collected from 19 electrodes, free from interictal EEG transients and artifacts, spectral analysis was performed using the FFT algorithm and color maps were produced by specialized equipment. Data were analyzed with respect to the presence of interhemispheric asymmetries and significant differences with age-matched normal controls. The topography of slow frequency components was the best clue for localization, with a concordance between imaging and spectral EEG data in 76% of the lesions detected by MRI. In 7 patients topographic mapping revealed spectral abnormalities in areas where MRI was not able to detect morphological lesions. These abnormalities were characterized by an increased delta (5 patients), theta (4 patients), or lowered ipsilateral alpha (1 patient) power. Although full agreement between imaging and electrophysiological data was not observed, we believe that in patients with TS the study of EEG rhythm activity can add valuable information to the visual inspection of the tracings.
一组10名患有结节性硬化症（TS）和癫痫的患者通过脑电图（EEG）和视觉诱发电位的地形图进行了研究。将该技术的定位能力与磁共振成像（MRI）上可见的T2加权高信号区域的地形图进行了比较。从19个电极收集数据，排除发作间期EEG瞬变和伪迹，使用快速傅里叶变换（FFT）算法进行频谱分析，并由专用设备生成彩色图谱。分析数据以确定半球间不对称的存在以及与年龄匹配的正常对照的显著差异。低频成分的地形图是定位的最佳线索，MRI检测到的病变中76%的成像和EEG频谱数据一致。在7名患者中，地形图显示MRI无法检测到形态学病变的区域存在频谱异常。这些异常的特征是δ波功率增加（5名患者）、θ波功率增加（4名患者）或同侧α波功率降低（1名患者）。尽管未观察到成像和电生理数据完全一致，但我们认为，对于结节性硬化症患者，EEG节律活动的研究可为脑电图的目视检查增添有价值的信息。
