Rozental J M
Wm. S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.
Neurol Clin. 1991 May;9(2):287-305.
In summary, PET and SPECT are versatile imaging modalities capable of providing dynamic information regarding the metabolism and physiology of brain and brain tumor. PET and SPECT are useful adjuncts to MRI and CT scanning in the important clinical areas of presurgical estimations of tumor grade. In addition, PET can be used to differentiate tumor necrosis from recurrence noninvasively, which is important for patient management. PET also may prove useful in early assessments of metabolic and physiologic changes in brain tumors following treatment and in monitoring drug delivery to tumor. Studies of drug delivery to and metabolic and physiologic responses of brain and brain tumor to treatment provide a quantitative handle on tumor response and patient prognosis. The ability to acquire such quantitative data may lead in the future to more efficient brain tumor treatment algorithms and to the development of more effective treatment protocols.
总之，正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）是多功能成像方式，能够提供有关脑和脑肿瘤代谢及生理的动态信息。在肿瘤分级的术前评估这一重要临床领域，PET和SPECT是磁共振成像（MRI）和计算机断层扫描（CT）的有用辅助手段。此外，PET可用于无创区分肿瘤坏死与复发，这对患者管理很重要。PET在治疗后脑肿瘤代谢和生理变化的早期评估以及监测药物向肿瘤的递送方面也可能证明是有用的。对药物向脑和脑肿瘤的递送以及脑和脑肿瘤对治疗的代谢和生理反应的研究为肿瘤反应和患者预后提供了定量依据。获取此类定量数据的能力未来可能会带来更有效的脑肿瘤治疗算法，并推动更有效的治疗方案的发展。
