Hanyu N, Aoki T, Ohira Y, Nakada K, Iikura M, Fukuda S, Hashimoto Y
Second Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
Nihon Geka Gakkai Zasshi. 1991 Sep;92(9):1189-92.
Postgastrectomy cholelithiasis has become a problem and biliary tract dyskinesia has been cited as an etiologic factor. CCK is the most important gut hormone with respect to biliary tract function, so we conducted an experimental study of postgastrectomy gallbladder function and CCK levels which gave the following results: 1. Although postprandial gallbladder contraction for the most part occurred in response to endogenous CCK, another mechanism (the gastro-cholecystic reflex) seemed to be responsible for some of them. 2. The postgastrectomy decrease in postprandial gallbladder contraction appeared to be due to disappearance of this gastro-cholecystic reflex. 3. Gallbladder contraction occurred in association with postprandial CCK secretion following total gastrectomy and Roux-en-Y reconstruction, but the altered food passage route caused changes in the dynamics of CCK secretion, and this is believed to have had an influence on the gallbladder contractile response.
胃切除术后胆石症已成为一个问题，胆道运动障碍被认为是一个病因。就胆道功能而言，胆囊收缩素（CCK）是最重要的胃肠激素，因此我们对胃切除术后胆囊功能和CCK水平进行了一项实验研究，结果如下：1. 虽然餐后胆囊收缩大部分是对内源性CCK的反应，但另一种机制（胃胆囊反射）似乎也起了一定作用。2. 胃切除术后餐后胆囊收缩的减少似乎是由于这种胃胆囊反射的消失。3. 全胃切除和Roux-en-Y重建术后，胆囊收缩与餐后CCK分泌有关，但食物通过途径的改变导致了CCK分泌动态的变化，这被认为对胆囊收缩反应有影响。
