Goya T, Doi F, Morisaki T, Torisu M, Shimura H
First Department of Surgery, Kyushu University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1991 Sep;92(9):1304-6.
We investigated the pathogenesis of septic-MOF through the relationship between changes in neutrophil functions and degree of complement activation. The patients' neutrophils exhibited enhanced adherence to HUVEC, suppressed chemotaxis toward C5a, enhanced production of oxygen radicals and lysosomal enzymes. These changes in neutrophil functions related to complement activation elicited via classical pathway. Moreover, the activated complement participated in tissue injuries due to the cytolytic action of the terminal complement complexes such as membrane attack complex (MAC). In conclusion, the combination of neutrophil and complement was strongly associated with the pathogenesis of the septic-MOF.
我们通过中性粒细胞功能变化与补体激活程度之间的关系，研究了脓毒症多器官功能障碍综合征（septic-MOF）的发病机制。患者的中性粒细胞表现出对人脐静脉内皮细胞（HUVEC）的黏附增强、对C5a趋化性受抑制、氧自由基和溶酶体酶产生增加。中性粒细胞功能的这些变化与通过经典途径引发的补体激活有关。此外，活化的补体通过膜攻击复合物（MAC）等终末补体复合物的溶细胞作用参与组织损伤。总之，中性粒细胞与补体的联合作用与脓毒症多器官功能障碍综合征的发病机制密切相关。
