Discovery of novel plant peptides as strong inhibitors of metalloproteinases.
作者信息
Carrilho Dina M, Duarte Isabel C, Francisco Rita, Ricardo Cândido P P, Duque-Magalhães Maria C
机构信息
Instituto Superior de Agronomia, Universidade Técnica de Lisboa, Departamento de Botânica e Engenharia Biológica, 1349-017 Lisbon, Portugal.
出版信息
Protein Pept Lett. 2009;16(5):543-51. doi: 10.2174/092986609788167789.
PMID:19442234
Abstract
Five novel metalloproteinase protein inhibitors (MPIs) with molecular mass between 5.6 and 8.9 kDa and acid/neutral pI were detected in lupin seeds and exhibited strong inhibitory activities against thermolysin and/or gelatinase B. These novel peptides constitute not only the first MPIs described in plants but also the first plant peptides with inhibitory activity against a matrixin.
摘要
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