Paschalis Alec, Churchill Linda, Marina Nephtali, Kasymov Vitaliy, Gourine Alexander, Ackland Gareth
Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Neurosci Lett. 2009 Jul 17;458(2):84-8. doi: 10.1016/j.neulet.2009.04.023. Epub 2009 Apr 15.
Current knowledge of the central nervous system distribution of the beta(1)-adrenergic receptors (beta(1)-AR) is incomplete. Here we present a general map of the beta(1)-AR distribution in the rat brain. beta(1)-AR-immunoreactivity was detected throughout the entire rat brain, but particularly dense staining was observed in the cerebellar cortex and basal ganglia. Brainstem areas displaying significant beta(1)-AR-immunoreactivity include the ventrolateral medulla, nucleus ambiguus and the nucleus of the solitary tract. Within the hypothalamus, only the paraventricular nucleus and the median eminence (ME) showed beta(1)-AR immunostaining. Numerous beta(1)-AR-immunoreactive cells were also found in the hippocampus, basal ganglia and cerebral cortex. These results extend our knowledge of the expression profile of beta(1)-AR in the central nervous system. The identification of several distinct beta(1)-AR immunoreactive substrates linked with neuropathophysiological roles in cardiovascular disease supports the hypothesis that the therapeutic benefit of beta(1)-AR blockade may be conferred at least in part through central nervous system mechanisms.
目前关于β₁ - 肾上腺素能受体（β₁ - AR）在中枢神经系统分布的认识并不完整。在此，我们展示大鼠脑中β₁ - AR分布的总图。在整个大鼠脑中均检测到β₁ - AR免疫反应性，但在小脑皮质和基底神经节中观察到特别密集的染色。显示出显著β₁ - AR免疫反应性的脑干区域包括延髓腹外侧、疑核和孤束核。在下丘脑中，仅室旁核和正中隆起（ME）显示β₁ - AR免疫染色。在海马体、基底神经节和大脑皮质中也发现了许多β₁ - AR免疫反应性细胞。这些结果扩展了我们对β₁ - AR在中枢神经系统中表达谱的认识。鉴定出几种与心血管疾病神经病理生理作用相关的不同β₁ - AR免疫反应性底物，支持了这样一种假说，即β₁ - AR阻滞剂的治疗益处可能至少部分通过中枢神经系统机制实现。
