Heazell A E P, Sahasrabudhe N, Grossmith A K, Martindale E A, Bhatia K
Maternal and Fetal Health Research Group, University of Manchester, St Mary's Hospital, Manchester M13 0JH, UK.
Placenta. 2009 Jul;30(7):654-7. doi: 10.1016/j.placenta.2009.04.004. Epub 2009 May 13.
Placental mesenchymal dysplasia (PMD) is a rare human disorder associated with stillbirth, intrauterine growth restriction (IUGR) and Beckwith-Wiedemann syndrome. Although the morphology of this condition has been described in 86 cases, the underlying cellular origin is unclear. We investigate the placental cell type involved in a case of PMD associated with a live born female infant with IUGR. In PMD intermediate villi contain cisternae, lined by non-proliferative cells. Immunostaining reveals they are not of trophoblast or vascular endothelial origin. There is positive immunostaining for lymphatic endothelium; this abnormal lymphangiogenesis is in concordance with current hypotheses regarding the aetiology of PMD. Furthermore, such observations suggest that placental villous mesenchyme may differentiate into various cell types, even those not normally found in the human placenta.
胎盘间充质发育异常（PMD）是一种罕见的人类疾病，与死产、宫内生长受限（IUGR）和贝克威思-维德曼综合征相关。尽管已对86例该病症的形态进行了描述，但其潜在的细胞起源尚不清楚。我们研究了一例与患有IUGR的活产女婴相关的PMD病例中所涉及的胎盘细胞类型。在PMD中，中间绒毛含有池，内衬非增殖细胞。免疫染色显示它们并非滋养层或血管内皮起源。淋巴管内皮有阳性免疫染色；这种异常的淋巴管生成与目前关于PMD病因的假说一致。此外，这些观察结果表明胎盘绒毛间充质可能分化为各种细胞类型，甚至是那些在人类胎盘中通常不存在的细胞类型。
