Sengers Florien B, van Lijnschoten Gesina, van der Sluijs-Bens Jacqueline P, Porath Martina M, Dijkman Koen P
Máxima Medisch Centrum, Veldhoven, afd. Kindergeneeskunde en Neonatologie, Veldhoven, The Netherlands.
Ned Tijdschr Geneeskd. 2010;154:A1040.
Two premature babies were admitted separately to the Neonatal Intensive Care Unit. One patient, a girl, presented with severe anaemia and thrombocytopaenia, the other, another girl, showed isolated thrombocytopaenia. During both pregnancies, ultrasound showed abnormalities of the placenta. The first patient also had intra-uterine growth restriction. A postpartum pathological examination showed abnormalities of both placentae consistent with placental mesenchymal dysplasia. Placental mesenchymal dysplasia is a rare condition which is associated with intra-uterine growth restriction, intra-uterine mortality, prematurity and Beckwith-Wiedemann syndrome. Thrombocytopaenia and anaemia are less commonly described in literature and are caused by micro-angiopathic haemolysis in the placenta. Both children had unrestricted growth and development patterns at one year and 6 months follow-up, respectively.
两名早产儿分别被收治入新生儿重症监护病房。一名女患者表现为严重贫血和血小板减少，另一名女患者则仅有血小板减少。在两次妊娠期间，超声检查均显示胎盘异常。第一名患者还存在宫内生长受限。产后病理检查显示两个胎盘均有异常，符合胎盘间质性发育异常。胎盘间质性发育异常是一种罕见疾病，与宫内生长受限、宫内死亡、早产和贝克威思-维德曼综合征有关。血小板减少和贫血在文献中较少被描述，是由胎盘微血管病性溶血引起的。分别在随访1年和6个月时，两名患儿的生长发育模式均未受限制。
