Buonomo O, Orsaria P, Contino G, Varvaras D, Gioia A, Bonanno E, Pistolese C, Cossu E, Perretta T, Schillaci O, Del Monte G, Roselli M, Mineo T C, Petrella G
Department of Surgery, Tor Vergata University, Rome, Italy.
Anticancer Res. 2009 May;29(5):1499-506.
Ductal intraepitelial neoplasia (DIN) represents a spectrum of disease that may progress from usual hyperplasia to ductal carcinoma in situ (DCIS) grade 3. The aim of the study was to asses the correlation between the DIN classification and the surgical treatment including sentinel lymph node biopsy (SLNB).
In this retrospective study, 229 patients with DIN had undergone conservative or radical surgical treatment and SLNB in cases of DIN1C-DIN3.
Breast conservative surgery was the definitive treatment in 80% of the cases. The H&E evaluation of excised sentinel nodes was negative for metastatic disease; nevertheless the immunohistochemical (IHC) evaluation revealed the presence of metastatic cells in 6 patients (3.7%).
In cases of DIN lesions SLNB is not indicated. The only reason SLNB should be considered is when there is an evidence of invasive foci at definitive histology or when radical mastectomy is proposed.
导管上皮内瘤变（DIN）代表了一系列疾病，其可能从普通增生发展为3级导管原位癌（DCIS）。本研究的目的是评估DIN分类与包括前哨淋巴结活检（SLNB）在内的手术治疗之间的相关性。
在这项回顾性研究中，229例DIN患者接受了保守或根治性手术治疗，对于DIN1C-DIN3的病例进行了前哨淋巴结活检。
80%的病例中，保乳手术是最终治疗方式。切除的前哨淋巴结的苏木精-伊红（H&E）评估显示无转移疾病；然而，免疫组化（IHC）评估在6例患者（3.7%）中发现了转移细胞。
对于DIN病变，不建议进行前哨淋巴结活检。考虑进行前哨淋巴结活检的唯一原因是在最终组织学检查中有浸润灶的证据或建议进行根治性乳房切除术时。
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