Hardy R, Cooper M S
School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham, UK.
J Endocrinol. 2009 Jun;201(3):309-20. doi: 10.1677/JOE-08-0568.
Chronic inflammatory diseases of almost any cause are associated with bone loss. Bone loss is due to direct effects of inflammation, poor nutrition, reduced lean body mass, immobility and the effects of treatments, especially glucocorticoids. These mechanisms are complex and interrelated but are ultimately mediated through effects on the bone remodelling cycle. Inflammatory disease can increase bone resorption, decrease bone formation but most commonly impacts on both of these processes resulting in an uncoupling of bone formation from resorption in favour of excess resorption. This review will illustrate these interactions between inflammation and bone metabolism and discuss how these are, and might be, manipulated as therapies for inflammation related bone loss.
几乎任何病因引起的慢性炎症性疾病都与骨质流失有关。骨质流失是由炎症的直接影响、营养不良、瘦体重减少、活动受限以及治疗的影响，尤其是糖皮质激素的影响所致。这些机制复杂且相互关联，但最终是通过对骨重塑周期的影响来介导的。炎症性疾病可增加骨吸收、减少骨形成，但最常见的是影响这两个过程，导致骨形成与吸收解偶联，有利于过度吸收。本综述将阐述炎症与骨代谢之间的这些相互作用，并讨论如何将这些相互作用作为炎症相关骨质流失的治疗方法进行利用，以及可能如何利用。
