人类垂体激素分泌颗粒直径分析

Analysis of diameters of human pituitary hormone secretory granules.

作者信息

Gray A B

出版信息

Acta Endocrinol (Copenh). 1977 Jun;85(2):249-55. doi: 10.1530/acta.0.0850249.

DOI:10.1530/acta.0.0850249

PMID:194441

Abstract

Measurements were made on electron micrographs of six human anterior pituitary glands of the maximal diameters of secretory granules in 130 cells, average 91 granules per cell. This was done in an attempt to classify the various hormone types solely by differences in the mean diameters of the secretory granules. The range of diameters in nanometers could be segregated into six subgroups of the following suggested functions: 135.5 +/- 13.6 TSH, 181.6 +/- 9.3 LH, 226.0 +/- 19.4 FSH, 356.8 +/- 30.5 ACTH/MSH, 452.9 +/- 23.8 GH, 559.9 +/- 38.0 prolactin.

摘要

对6个人类垂体前叶的电子显微照片进行了测量，测定了130个细胞中分泌颗粒的最大直径，平均每个细胞有91个颗粒。这样做是为了仅通过分泌颗粒平均直径的差异对各种激素类型进行分类。以纳米为单位的直径范围可分为以下具有不同功能的六个亚组：促甲状腺激素（TSH）为135.5±13.6，促黄体生成素（LH）为181.6±9.3，促卵泡生成素（FSH）为226.0±19.4，促肾上腺皮质激素/促黑素（ACTH/MSH）为356.8±30.5，生长激素（GH）为452.9±23.8，催乳素为559.9±38.0。