结直肠癌的小鼠模型。
Murine models of colorectal cancer.
作者信息
Uronis Joshua M, Threadgill David W
机构信息
Curriculum in Genetics and Molecular Biology, Department of Genetics, Lineberger Cancer Center and Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Mamm Genome. 2009 May;20(5):261-8. doi: 10.1007/s00335-009-9186-5. Epub 2009 May 15.
Abstract
Colorectal cancer is one of the most prevalent cancers of humans. To experimentally investigate this common disease, numerous murine models have been established. These models accurately recapitulate the molecular and pathologic characteristics of human colorectal cancers, including activation of the myelocytomatosis oncogene (MYC), which has recently been suggested to be a key mediator of colorectal cancer development. This review focuses on the variety of murine models of human colorectal cancer that are available to the research community and on their use to identify common and distinct characteristics of colorectal cancer.
摘要
结直肠癌是人类最常见的癌症之一。为了通过实验研究这种常见疾病，已经建立了许多小鼠模型。这些模型准确地概括了人类结直肠癌的分子和病理特征，包括髓细胞瘤致癌基因（MYC）的激活，最近有人提出该基因是结直肠癌发展的关键介质。这篇综述重点介绍了研究界可用的各种人类结直肠癌小鼠模型，以及它们在识别结直肠癌共同和独特特征方面的应用。
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