Wirtz Stefan, Neurath Markus F
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany.
Adv Drug Deliv Rev. 2007 Sep 30;59(11):1073-83. doi: 10.1016/j.addr.2007.07.003. Epub 2007 Aug 16.
Animal models of intestinal inflammation are indispensable for our understanding of the pathogenesis of Crohn disease and Ulcerative colitis, the idiopathic forms of inflammatory bowel disease in humans. The clinical appearance of human IBD is heterogeneous, a fact that is also reflected by the steadily increasing number of mouse strains displaying IBD like intestinal alterations. The analysis of these models together with genetic studies in humans greatly enhanced our insights into immunoregulatory processes in the gut and led to the generally accepted hypothesis that a deregulated immune response against components of the intestinal microbiota is critically involved in IBD pathophysiology. In this article we provide a brief overview of selected mouse models of IBD and discuss their contribution to the current understanding of disease mechanisms that contribute to IBD.
肠道炎症的动物模型对于我们理解克罗恩病和溃疡性结肠炎（人类特发性炎症性肠病的两种形式）的发病机制不可或缺。人类炎症性肠病的临床表现具有异质性，这一事实也体现在表现出类似炎症性肠病肠道改变的小鼠品系数量不断增加上。对这些模型的分析以及人类遗传学研究极大地增进了我们对肠道免疫调节过程的认识，并得出了一个被广泛接受的假说，即针对肠道微生物群成分的免疫反应失调在炎症性肠病的病理生理学中起着关键作用。在本文中，我们简要概述了选定的炎症性肠病小鼠模型，并讨论它们对当前对导致炎症性肠病的疾病机制理解的贡献。
