André N, Pasquier E, Verschuur A, Sterba J, Gentet J-C, Rössler J
Service d'oncologie pédiatrique, hôpital pour enfants de La-Timone, boulevard Jean-Moulin, 13005 Marseille, France.
Arch Pediatr. 2009 Aug;16(8):1158-65. doi: 10.1016/j.arcped.2009.03.019. Epub 2009 May 14.
Angiogenesis is crucial for the growth of cancer. As such, it has become an established target in fighting cancer. Metronomic chemotherapy-the chronic administration of chemotherapy at relatively low, minimally toxic doses on a frequent schedule of administration at close regular intervals, with no prolonged drug-free breaks-is a potential novel approach to controlling advanced cancer disease. It is thought to work primarily through antiangiogenic mechanisms and has the property of killing resistant cancer cells while significantly reducing undesirable toxic side effects. We review the data regarding the use of metronomic chemotherapy in children with cancer and discuss its potential uses and limits.
血管生成对癌症的生长至关重要。因此，它已成为抗癌的既定靶点。节拍式化疗——以相对较低、毒性最小的剂量，按紧密的固定间隔频繁给药进行长期化疗，且无延长的无药间歇期——是控制晚期癌症疾病的一种潜在新方法。它被认为主要通过抗血管生成机制起作用，具有杀死耐药癌细胞同时显著减少不良毒副作用的特性。我们综述了有关节拍式化疗在癌症患儿中应用的数据，并讨论了其潜在用途和局限性。
