García Cuartero B, González Vergaz A, Herranz S, Vázquez M C, Carvajal O, Carpintero P, Gutierrez P
Unidad de Endocrinología Pediátrica, Servicio de Pediatría Hospital Universitario Severo Ochoa, Leganés Madrid, Spain.
An Pediatr (Barc). 2009 Jun;70(6):542-6. doi: 10.1016/j.anpedi.2009.02.013. Epub 2009 May 14.
Over recent years, the increasing incidence of type 1 diabetes mellitus (T1DM) has been associated with different factors, particularly increased obesity in childhood. The aim of this study was to find out if there was any relationship between birth weight, body mass index (BMI) increase during the first two 3 years of life, and BMI at diabetes onset with age at diagnosis, in a cohort of children diagnosed with T1DM.
Data from 100 Caucasian children with T1DM of both sexes (57 boys, 43 girls) between 10 months and 16 years of age, mean age 84.45 months (SD; 52.4), were studied. We analysed the following variables: age at diagnosis, gestational age, weight and height at birth, at two years of age and at diabetes diagnosis, expressed as SD scores (SDS).
All children were between 38-40 weeks of gestational age. Diabetic patients have lower birth weight (-2.88 ((-0.51)-(-0.066)) and lower BMI at birth compared with healthy children -0.5 ((-0.77)-(-0.23)). Diabetic children have a significant increase in BMI during the first two years of life (4.58 versus 2.17; P<0.001). Children with the lowest BMI at birth (12.77 versus 13.06; P<0.006) are the youngest at onset of the disease. BMI at diagnosis was not related to any of the variables studied. There were no gender differences either.
The low BMI at birth and the later increase in the following years of life seem to be related to intrauterine environment as a risk factor for T1DM.
近年来，1型糖尿病（T1DM）发病率的上升与多种因素相关，尤其是儿童肥胖率的增加。本研究旨在探讨在一组被诊断为T1DM的儿童中，出生体重、生命最初两年的体重指数（BMI）增长以及糖尿病发病时的BMI与诊断年龄之间是否存在任何关系。
研究了100名10个月至16岁的白种人T1DM患儿（57名男孩，43名女孩）的数据，平均年龄84.45个月（标准差；52.4）。我们分析了以下变量：诊断年龄、胎龄、出生时、两岁时以及糖尿病诊断时的体重和身高，以标准差分数（SDS）表示。
所有儿童的胎龄均在38 - 40周之间。与健康儿童相比，糖尿病患者出生体重较低（-2.88（（-0.51）-（-0.066）），出生时BMI也较低 -0.5（（-0.77）-（-0.23））。糖尿病儿童在生命的头两年BMI显著增加（4.58对2.17；P<0.001）。出生时BMI最低的儿童（12.77对13.06；P<0.006）发病年龄最小。诊断时的BMI与所研究的任何变量均无关联。也没有性别差异。
出生时BMI较低以及随后几年中BMI的后期增加似乎与子宫内环境有关，子宫内环境是T1DM的一个风险因素。
