Svensson Jannet, Carstensen Bendix, Mortensen Henrik B, Borch-Johnsen Knut
Steno Diabetes Centre, Gentofte, Denmark.
Paediatr Perinat Epidemiol. 2007 Jan;21(1):44-8. doi: 10.1111/j.1365-3016.2007.00775.x.
The aim of the study was to investigate whether growth parameters at birth and age 1 year were associated with type 1 diabetes (T1D) in the Danish population and to what extent this explains the increase in T1D incidence. The study is a population-based case-control study; it compares 490 cases from the Danish diabetes register 1996-99 aged 0-14 years and 696 randomly selected controls (2 per case) from the population register matched for gender and date of birth. We found an increased risk of T1D during childhood in children with a body mass index (BMI) on or above two standard deviations at age 1 year (OR = 3.77 [95% CI 1.41, 10.1]). Children developing diabetes were significantly taller at age 1 year (OR = 1.04 [95% CI 1.00, 1.08]). Children born 1981-99 have significantly higher BMI and weight at birth and a significantly lower BMI and weight at age 1 year compared with children born 1966-74. Thus the increasing incidence of T1D could not be explained by changes in growth parameters at birth or at age 1 year.
该研究的目的是调查丹麦人群中出生时及1岁时的生长参数是否与1型糖尿病（T1D）相关，以及这在多大程度上解释了T1D发病率的上升。该研究是一项基于人群的病例对照研究；它比较了1996 - 1999年丹麦糖尿病登记处的490例0 - 14岁的病例，以及从人口登记处随机选取的696名对照（每个病例2名），这些对照按性别和出生日期进行匹配。我们发现，1岁时体重指数（BMI）处于或高于两个标准差的儿童在童年期患T1D的风险增加（比值比[OR] = 3.77 [95%置信区间1.41, 10.1]）。患糖尿病的儿童在1岁时显著更高（OR = 1.04 [95%置信区间1.00, 1.08]）。与1966 - 1974年出生的儿童相比，1981 - 1999年出生的儿童出生时BMI和体重显著更高，而1岁时BMI和体重显著更低。因此，T1D发病率的上升无法用出生时或1岁时生长参数的变化来解释。
