Liu Jie, Song Bao, Wang Zhehai, Song Xianrang, Shi Yan, Zheng Jingsong, Han Jinxiang
Department of Oncology, Shandong Cancer Hospital & Institute, 440 Jiyan Road, Jinan 250117, Shandong, P R China.
Cancer Genet Cytogenet. 2009 Jun;191(2):67-72. doi: 10.1016/j.cancergencyto.2009.01.015.
Genetic polymorphism in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with cancer risks. This hospital-based case-control study examined whether polymorphism in the DNA repair gene x-ray repair cross-complementing groups 1 (XRCC1 Arg194Trp [C-->T], Arg280His [G-->A], and Arg399Gln [G-->A]) played a role in susceptibility to non-Hodgkin's lymphoma (NHL) in the Chinese population. We genotyped these polymorphisms for 221 histopathologically confirmed NHL cases and 254 age- and sex-matched healthy control cases in China. No studied polymorphism alone was shown to be related to the risk of NHL or each histologic subtype of NHL. When stratified by smoking status, however, the XRCC1Arg399Gln variant genotypes (homozygotes and heterozygotes) were associated with a 3.0-fold risk of follicular lymphoma among heavy smokers (95% confidence interval: 1.16-7.82; P = 0.02). Further large-scale studies would confirm this association and clarify marginally significant trends in XRCC1 polymorphism combinations for an increased risk for NHL.
DNA修复基因中的遗传多态性可能会影响个体在DNA修复能力上的差异，这可能与癌症风险相关。这项基于医院的病例对照研究调查了DNA修复基因X射线修复交叉互补组1（XRCC1 Arg194Trp [C→T]、Arg280His [G→A]和Arg399Gln [G→A]）中的多态性是否在中国人群非霍奇金淋巴瘤（NHL）易感性中起作用。我们对中国221例经组织病理学确诊的NHL病例和254例年龄及性别匹配的健康对照病例进行了这些多态性的基因分型。单独的研究多态性均未显示与NHL风险或NHL的每种组织学亚型相关。然而，按吸烟状况分层时，XRCC1 Arg399Gln变异基因型（纯合子和杂合子）与重度吸烟者中滤泡性淋巴瘤风险增加3.0倍相关（95%置信区间：1.16 - 7.82；P = 0.02）。进一步的大规模研究将证实这种关联，并阐明XRCC1多态性组合中对于NHL风险增加的边缘显著趋势。
