Sen Gautam, Pal Sagar
Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.
Int J Biol Macromol. 2009 Jul 1;45(1):48-55. doi: 10.1016/j.ijbiomac.2009.03.012. Epub 2009 Apr 5.
This paper reports the investigation of microwave initiated synthesized polyacrylamide grafted carboxymethylstarch (CMS-g-PAM) as matrix for sustained drug release. 'In vitro' release of a model drug (5-amino salicylic acid) from CMS-g-PAM matrix has been studied. It is evident that higher the percentage grafting, more sustained is the rate of drug release. Further, the percentage grafting vs. t(50) value (i.e. time taken for release of 50% of the enclosed drug) correlation has been successfully studied for the first time. This correlation will lead to the possibility of a programmable drug release matrix based on grafted polysaccharide. In this matrix, the rate of release of the enclosed drug can be precisely programmed simply by adjustment of percentage grafting during synthesis.
本文报道了对微波引发合成的聚丙烯酰胺接枝羧甲基淀粉（CMS-g-PAM）作为药物缓释基质的研究。已对模型药物（5-氨基水杨酸）从CMS-g-PAM基质中的“体外”释放进行了研究。显然，接枝百分比越高，药物释放速率越持久。此外，首次成功研究了接枝百分比与t(50)值（即释放50%包封药物所需的时间）之间的相关性。这种相关性将使基于接枝多糖的可编程药物释放基质成为可能。在这种基质中，只需在合成过程中调整接枝百分比，就能精确地对包封药物的释放速率进行编程。
