Usha Rani G, Konreddy Ananda Kumar, Mishra Sumit, Sen Gautam
Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi 835 215, Jharkhand, India.
Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi 835 215, Jharkhand, India.
Int J Biol Macromol. 2014 Apr;65:375-82. doi: 10.1016/j.ijbiomac.2014.01.034. Epub 2014 Feb 5.
Agar has been modified by microwave assisted grafting with acrylamide monomer, resulting in poly acrylamide grafted agar (Ag-g-PAM). The synthesized grades of Ag-g-PAM were characterized by standard physico-chemical characterization techniques (FTIR spectroscopy, elemental analysis, scanning electron microscopy (SEM)) to ascertain the intended grafting. The synthesized graft copolymer (Ag-g-PAM) has been investigated (in vitro) for controlled and colon targeted release of 5-amino salicylic acid (5-ASA).
琼脂已通过微波辅助与丙烯酰胺单体接枝进行改性，得到聚丙烯酰胺接枝琼脂（Ag-g-PAM）。采用标准的物理化学表征技术（傅里叶变换红外光谱、元素分析、扫描电子显微镜（SEM））对合成的Ag-g-PAM进行表征，以确定预期的接枝情况。对合成的接枝共聚物（Ag-g-PAM）进行了体外研究，以考察其对5-氨基水杨酸（5-ASA）的控释和结肠靶向释放性能。
