Fonoff Erich Talamoni, Pereira Jose Francisco, Camargo Leonardo Valente, Dale Camila Squarzoni, Pagano Rosana Lima, Ballester Gerson, Teixeira Manoel Jacobsen
Teaching and Research Institute, Hospital Sírio-Libanês, São Paulo, SP, Brazil.
Behav Brain Res. 2009 Aug 24;202(1):138-41. doi: 10.1016/j.bbr.2009.03.018. Epub 2009 Mar 24.
Motor cortex stimulation oriented by functional cortical mapping is used mainly for treating otherwise intractable neurological disorders, however, its mechanism of action remains elusive. Herein, we present a new method for functional mapping of the rat motor cortex using non-invasive transdural electrical stimulation. This method allows a non-invasive mapping of the surface of the neocortex providing a differentiation of representative motor areas. This study may facilitate further investigation about the mechanisms mediating the effects of electrical stimulation, possibly benefiting patients who do not respond to this neuromodulation therapy.
通过功能皮质映射导向的运动皮质刺激主要用于治疗其他难以治疗的神经系统疾病，然而，其作用机制仍然难以捉摸。在此，我们提出了一种使用非侵入性经硬脑膜电刺激对大鼠运动皮质进行功能映射的新方法。该方法允许对新皮质表面进行非侵入性映射，从而区分代表性运动区域。这项研究可能有助于进一步研究介导电刺激作用的机制，可能使对这种神经调节疗法无反应的患者受益。
