Yang Xiao, Zhang Hui, Yuan Xiaoliang, Cui Shuxun
State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China.
J Colloid Interface Sci. 2009 Aug 15;336(2):756-60. doi: 10.1016/j.jcis.2009.04.050. Epub 2009 May 3.
We utilize the extracted water-soluble wool keratin as the building block for the layer-by-layer (LbL) assembly. By adjusting the solution pH, keratin can be used as polycation or polyanion. Experimental results indicate that multilayer films of keratin together with other synthetic polyelectrolytes have been fabricated successfully. We have found that the average thickness of each bilayer of the keratin containing film is evidently larger than that of usual multilayer films previously reported. This feature is helpful to fabricate relatively thick films in less deposition cycles. The use of keratin in LbL assembly is helpful to prepare a biocompatible surface for tissue engineering.
我们利用提取的水溶性羊毛角蛋白作为层层（LbL）组装的构建单元。通过调节溶液的pH值，角蛋白可以用作聚阳离子或聚阴离子。实验结果表明，角蛋白与其他合成聚电解质的多层膜已成功制备。我们发现，含角蛋白薄膜的每个双层的平均厚度明显大于先前报道的普通多层膜。这一特性有助于在较少的沉积循环中制备相对较厚的薄膜。在LbL组装中使用角蛋白有助于为组织工程制备生物相容性表面。
