Rajamaki Suvi, Innitzer Anna, Falciani Chiara, Tintori Cristina, Christ Frauke, Witvrouw Myriam, Debyser Zeger, Massa Silvio, Botta Maurizio
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. De Gasperi 2, I-53100 Siena, Italy.
Bioorg Med Chem Lett. 2009 Jul 1;19(13):3615-8. doi: 10.1016/j.bmcl.2009.04.132. Epub 2009 May 3.
A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity both in enzymatic and cellular assays.
通过虚拟筛选技术已鉴定出一种新型的抑制HIV-1整合酶的化合物。已合成了一小类结构相关的分子，并进行了生物学评估，其中一些化合物在酶促和细胞试验中具有微摩尔活性。
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