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特权支架协会——一种抑制所有支架的结构。

The Fellowship of Privileged Scaffolds-One Structure to Inhibit Them All.

作者信息

Skoreński Marcin, Sieńczyk Marcin

机构信息

Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wrocław, Poland.

出版信息

Pharmaceuticals (Basel). 2021 Nov 16;14(11):1164. doi: 10.3390/ph14111164.

Abstract

Over the past few years, the application of privileged structure has emerged as a powerful approach to the discovery of new biologically active molecules. Privileged structures are molecular scaffolds with binding properties to the range of different biological targets. Moreover, privileged structures typically exhibit good drug-like properties, thus assuring more drug-like properties of modified compound. Our main objective is to discuss the privileged structures used for the development of antiviral agents.

摘要

在过去几年中,特权结构的应用已成为发现新的生物活性分子的一种强大方法。特权结构是对一系列不同生物靶点具有结合特性的分子骨架。此外,特权结构通常表现出良好的类药性质,从而确保修饰化合物具有更多的类药性质。我们的主要目标是讨论用于开发抗病毒药物的特权结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f8/8622370/f2e99c40a13a/pharmaceuticals-14-01164-g001.jpg

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