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16S 核糖体 DNA 测序在诊断凝固酶阴性葡萄球菌性自体瓣膜感染性心内膜炎中的应用：病例报告及文献复习。

Utility of 16S ribosomal DNA sequencing in the diagnosis of Staphylococcus lugdunensis native valve infective endocarditis: case report and literature review.

机构信息

Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433.

出版信息

Int J Infect Dis. 2009 Nov;13(6):e511-3. doi: 10.1016/j.ijid.2009.02.019. Epub 2009 May 17.

DOI:10.1016/j.ijid.2009.02.019
PMID:19447659
Abstract

We report a case of possible infective endocarditis without fever presenting with an acutely ischemic limb with prior antimicrobial therapy preventing identification by culture of a microorganism. 16S ribosomal DNA sequencing led to the identification of Staphylococcus lugdunensis from an embolus removed at surgery and subsequent successful antibiotic treatment. We review the utility of 16S ribosomal DNA sequencing in diagnosing infective endocarditis and other infectious conditions.

摘要

我们报告了一例可能的感染性心内膜炎病例，该病例无发热，表现为肢体急性缺血，且先前的抗菌治疗阻止了通过培养微生物来识别病原体。16S 核糖体 DNA 测序从手术切除的栓子中鉴定出了路邓葡萄球菌，随后进行了成功的抗生素治疗。我们回顾了 16S 核糖体 DNA 测序在诊断感染性心内膜炎和其他感染性疾病中的应用。

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引用本文的文献

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Clinical and microbiological characterization of Staphylococcus lugdunensis isolates obtained from clinical specimens in a hospital in China.
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