Zeuner K E, Peller M, Knutzen A, Groppa S, Holler I, Kopper F, Raethjen J, Dressler D, Hallett M, Deuschl G, Siebner H R
Department of Neurology, Christian-Albrechts-University Kiel, Arnold Heller Strasse 3, Haus 41, 24105 Kiel, Germany.
Clin Neurophysiol. 2009 Jun;120(6):1213-9. doi: 10.1016/j.clinph.2009.04.010. Epub 2009 May 17.
To investigate whether movement-related cortical potentials (MRCP) provide a physiological correlate that indicates the response to treatment in patients with writer's cramp.
In 21 patients with writer's cramp, who underwent 4 weeks of limb immobilization followed by re-training for 8 weeks, we recorded MRCPs preceding a self-initiated brisk finger abduction movement. MRCP measurements of pre-movement activity were performed at baseline, after the end of immobilization and four and 8 weeks of re-training. We examined 12 controls, who received no intervention, twice 4 weeks apart.
Patients benefited from the therapeutical intervention (Zeuner et al., 2008). They showed no abnormalities of the MRCPs at baseline. In controls, MRCPs did not significantly change after 4 weeks. In patients, immobilization and re-training had no effect on MRCPs. There was no correlation between the severity of dystonic symptoms or the individual treatment response and MRCPs.
MRCPs are stable measures for interventional studies. However, they do not reflect clinical severity of dystonic symptoms or improvement after therapeutic interventions.
This is the first study to investigate MRCPs in a large cohort of patients with writer's cramp compared to a control group at different time points. These potentials do not reflect the motor control disorder in patients with writer's cramp.
研究与运动相关的皮层电位（MRCP）是否能提供一种生理关联，以表明书写痉挛患者对治疗的反应。
对21例书写痉挛患者进行研究，这些患者先进行4周的肢体固定，随后进行8周的重新训练。在患者自主发起快速手指外展运动之前，我们记录MRCP。在基线、固定结束时以及重新训练4周和8周后，对运动前活动进行MRCP测量。我们检查了12名未接受干预的对照者，在相隔4周的时间里进行了两次检查。
患者从治疗干预中获益（Zeuner等人，2008年）。他们在基线时MRCP未显示异常。在对照者中，4周后MRCP没有显著变化。在患者中，固定和重新训练对MRCP没有影响。肌张力障碍症状的严重程度或个体治疗反应与MRCP之间没有相关性。
MRCP是用于干预研究的稳定测量指标。然而，它们不能反映肌张力障碍症状的临床严重程度或治疗干预后的改善情况。
这是第一项在一大群书写痉挛患者中，与对照组在不同时间点比较研究MRCP的研究。这些电位不能反映书写痉挛患者的运动控制障碍。
