Quartarone Angelo, Bagnato Sergio, Rizzo Vincenzo, Morgante Francesca, Sant'Angelo Antonino, Crupi Domenica, Romano Marcello, Messina Corrado, Berardelli Alfredo, Girlanda Paolo
Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Italy.
Mov Disord. 2005 Nov;20(11):1488-95. doi: 10.1002/mds.20626.
Motor imagery (MI) is the mental rehearsal of a motor act without overt movement. Using transcranial magnetic stimulation (TMS), we tested the effect of MI on corticospinal excitability in patients with writer's cramp. In 10 patients with writer's cramp and 10 healthy controls, we applied focal TMS over each primary motor area and recorded motor evoked potentials (MEPs) from contralateral hand and arm muscles while participants imagined a tonic abduction of the index finger contralateral to the stimulated hemisphere. In healthy controls and patients, the MEP amplitude in the relaxed first dorsal interosseus muscle (FDI) showed a muscle-specific increase during MI; however, the increase was less pronounced in patients than in healthy controls. In addition, in patients but not in controls, the MEP amplitude also increased in hand and forearm muscles not involved in the imagined movement. This abnormal spread of facilitation was observed in the affected and unaffected upper limb. MI of simple hand movements is less efficient and less focussed in patients with writer's cramp than it is in normal subjects.
运动想象（MI）是指在不进行明显动作的情况下对运动行为进行心理演练。我们使用经颅磁刺激（TMS）测试了运动想象对书写痉挛患者皮质脊髓兴奋性的影响。在10名书写痉挛患者和10名健康对照者中，我们在每个主要运动区域施加局灶性TMS，并在参与者想象受刺激半球对侧食指的强直性外展时，记录对侧手部和手臂肌肉的运动诱发电位（MEP）。在健康对照者和患者中，放松状态下第一背侧骨间肌（FDI）的MEP波幅在运动想象期间呈现出肌肉特异性增加；然而，患者的增加幅度不如健康对照者明显。此外，在患者而非对照者中，未参与想象运动的手部和前臂肌肉的MEP波幅也增加了。在患侧和未患侧上肢均观察到这种易化的异常扩散。与正常受试者相比，书写痉挛患者简单手部运动的运动想象效率更低且更不集中。
