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From IFN to TNF: a journey into realms of lore.

作者信息

Vilcek Jan

机构信息

Department of Microbiology, New York University Langone Medical Center, New York, New York, USA.

出版信息

Nat Immunol. 2009 Jun;10(6):555-7. doi: 10.1038/ni0609-555.

DOI:10.1038/ni0609-555
PMID:19448652
Abstract
摘要

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From IFN to TNF: a journey into realms of lore.从干扰素到肿瘤坏死因子：一段进入知识领域的旅程。
Nat Immunol. 2009 Jun;10(6):555-7. doi: 10.1038/ni0609-555.
2
Interferon-gamma rescues TNF-alpha-induced apoptosis mediated by up-regulation of TNFR2 on EoL-1 cells.干扰素-γ通过上调EoL-1细胞上的TNFR2拯救肿瘤坏死因子-α诱导的细胞凋亡。
Exp Hematol. 1999 Mar;27(3):512-9. doi: 10.1016/s0301-472x(98)00058-7.
3
Immunological basis for the use of TNFalpha-blocking agents in ankylosing spondylitis and immunological changes during treatment.肿瘤坏死因子α阻滞剂在强直性脊柱炎中应用的免疫学基础及治疗期间的免疫学变化
Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S34-7.
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Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis.肿瘤坏死因子阻滞剂影响巨噬细胞对结核分枝杆菌的反应。
J Infect Dis. 2008 Dec 15;198(12):1842-50. doi: 10.1086/593174.
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The effect of etanercept and infliximab on the production of tumour necrosis factor alpha, interferon-gamma and GM-CSF in in vivo activated intestinal T lymphocyte cultures.依那西普和英夫利昔单抗对体内活化的肠道T淋巴细胞培养物中肿瘤坏死因子α、干扰素-γ和粒细胞巨噬细胞集落刺激因子产生的影响。
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STAT-1 alpha and IFN-gamma as modulators of TNF-alpha signaling in macrophages: regulation and functional implications of the TNF receptor 1:STAT-1 alpha complex.STAT-1α和IFN-γ作为巨噬细胞中TNF-α信号传导的调节因子：TNF受体1:STAT-1α复合物的调控及其功能意义
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Antitumour necrosis factor-alpha chimeric antibody (infliximab) inhibits activation of skin-homing CD4+ and CD8+ T lymphocytes and impairs dendritic cell function.抗肿瘤坏死因子-α嵌合抗体（英夫利昔单抗）可抑制皮肤归巢性CD4+和CD8+ T淋巴细胞的活化，并损害树突状细胞功能。
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Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor.阿达木单抗、英夫利昔单抗和依那西普与可溶性及膜结合肿瘤坏死因子结合时的亲和力、亲合力及补体激活的比较
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Infliximab does not lead to reduction in the interferon-gamma and lymphoproliferative responses of patients with moderate to severe psoriasis.英夫利昔单抗不会导致中重度银屑病患者干扰素-γ和淋巴增殖反应减少。
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Blocking TNF in vitro with infliximab determines the inhibition of expansion and interferon gamma production of Vgamma9/Vdelta2 T lymphocytes from patients with active rheumatoid arthritis. A role in the susceptibility to tuberculosis?在体外使用英夫利昔单抗阻断肿瘤坏死因子（TNF）可抑制活动性类风湿关节炎患者Vγ9/Vδ2 T淋巴细胞的扩增和干扰素γ的产生。这与结核病易感性有关吗？
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HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis.HOIP 通过防止 TNF 和 IFN-γ诱导的细胞凋亡来限制抗肿瘤免疫。
EMBO Rep. 2021 Nov 4;22(11):e53391. doi: 10.15252/embr.202153391. Epub 2021 Sep 1.
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A fascinating story of the discovery & development of biologicals for use in clinical medicine.

本文引用的文献

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Interferon research BC (before cloning).
Curr Top Microbiol Immunol. 2007;316:9-22. doi: 10.1007/978-3-540-71329-6_2.
2
My fifty years with interferon.我与干扰素的五十年。
J Interferon Cytokine Res. 2007 Jul;27(7):535-42. doi: 10.1089/jir.2007.9984.
3
Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.五聚体蛋白处于固有免疫、炎症、基质沉积和女性生育能力的交叉点。
Annu Rev Immunol. 2005;23:337-66. doi: 10.1146/annurev.immunol.23.021704.115756.
一个关于生物制品在临床医学中应用的发现和发展的精彩故事。
Indian J Med Res. 2018 Sep;148(3):263-278. doi: 10.4103/ijmr.IJMR_1471_18.
4
Beyond Serendipity to an Algorithmic Approach.从偶然到算法方法
Plast Reconstr Surg Glob Open. 2018 Feb 6;6(2):e1675. doi: 10.1097/GOX.0000000000001675. eCollection 2018 Feb.
5
The high costs of "free" drug samples.“免费”药品样品的高昂成本。
Clin Transl Gastroenterol. 2014 Dec 18;5(12):e67. doi: 10.1038/ctg.2014.16.
6
Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells.巨噬细胞和间充质基质细胞支持多发性骨髓瘤细胞的存活和增殖。
Br J Haematol. 2012 Aug;158(3):336-46. doi: 10.1111/j.1365-2141.2012.09154.x. Epub 2012 May 15.
7
The birth pangs of monoclonal antibody therapeutics: the failure and legacy of Centoxin.单克隆抗体治疗药物的诞生之痛：抑瘤素 M 的失败与遗产。
MAbs. 2012 May-Jun;4(3):403-12. doi: 10.4161/mabs.19909. Epub 2012 Apr 26.
4
Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14.细胞因子诱导的基因表达处于固有免疫、炎症与生育能力的交叉点：TSG-6和PTX3/TSG-14
Cytokine Growth Factor Rev. 2004 Apr-Jun;15(2-3):129-46. doi: 10.1016/j.cytogfr.2004.01.005.
5
An interferon-like substance released from tickborne encephalitis virus-infected chick embryo fibroblast cells.一种从蜱传脑炎病毒感染的鸡胚成纤维细胞释放的类干扰素物质。
Nature. 1960 Jul 2;187:73-4. doi: 10.1038/187073a0.
6
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.用抗肿瘤坏死因子α嵌合单克隆抗体治疗类风湿性关节炎。
Arthritis Rheum. 1993 Dec;36(12):1681-90. doi: 10.1002/art.1780361206.
7
Construction and initial characterization of a mouse-human chimeric anti-TNF antibody.小鼠-人嵌合抗TNF抗体的构建及初步表征
Mol Immunol. 1993 Nov;30(16):1443-53. doi: 10.1016/0161-5890(93)90106-l.
8
TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins.TSG-14是一种肿瘤坏死因子和白细胞介素-1诱导蛋白，是急性期蛋白五聚素家族的一个新成员。
J Immunol. 1993 Mar 1;150(5):1804-12.
9
The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo.小鼠/人嵌合单克隆抗体cA2在体外可中和肿瘤坏死因子（TNF），并在体内保护转基因小鼠免受恶病质和TNF致死性的影响。
Cytokine. 1995 Jan;7(1):15-25. doi: 10.1006/cyto.1995.1003.
10
TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor.TSG-6是一种与关节炎相关的透明质酸结合蛋白，它与血清蛋白α-间抑制因子形成稳定的复合物。
Biochemistry. 1994 Jun 14;33(23):7423-9. doi: 10.1021/bi00189a049.